Magnetic Resonance Image-guided Focused Ultrasound Robotic System for Transrectal Prostate Cancer Therapy

Overview

Journal Int J Med Robot

Publisher Wiley

Specialties Biotechnology
General Surgery

Date 2021 Feb 3

PMID 33533112

Citations 10

Authors

Marinos Giannakou

Theocharis Drakos

Georgios Menikou

Nikolas Evripidou

Antria Filippou

Kyriakos Spanoudes

Leonidas Ioannou

Christakis Damianou

Affiliations

Soon will be listed here.

Abstract

Background: A magnetic resonance image (MRI) guided robotic device for focussed ultrasound therapy of prostate cancer (PC) was developed. The device offers movement in 5 degrees of freedom (DOF) and uses a single-element transducer that operates at 3.2 MHz, has a diameter of 25 mm and focuses at 45 mm.

Methods: The MRI compatibility of the system was evaluated in a 1.5 T scanner. The ability of the transducer to create lesions was evaluated in laboratory and MRI settings, on ex vivo pork tissue and in vivo rabbit thigh tissue.

Results: Cavitational and thermal lesions were created on the excised pork tissue. In vivo experiments proved the efficacy of the system in ablating muscle tissue without damaging intervening areas.

Conclusions: The MRI compatible robotic system can be placed on the table of any commercial MRI scanner up to 7 T. The device has the ability of future use for transrectal focal therapy of PC with the patient in supine position.

Citing Articles

Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3T.

Filippou A, Evripidou N, Georgiou A, Georgiou L, Chrysanthou A, Ioannides C J Med Phys. 2025; 49(4):583-596.

PMID: 39926130 PMC: 11801101. DOI: 10.4103/jmp.jmp_133_24.

Magnetic Resonance Imaging Monitoring of Thermal Lesions Produced by Focused Ultrasound.

Antoniou A, Evripidou N, Nikolaou A, Georgiou A, Giannakou M, Chrysanthou A J Med Ultrasound. 2025; 32(4):297-308.

PMID: 39801543 PMC: 11717076. DOI: 10.4103/jmu.jmu_112_23.

Towards Design and Development of an MRI Conditional Robot to Enable Curvilinear Transperineal Prostate Biopsy.

Lafreniere S, Padasdao B, Konh B Int J Med Robot. 2024; 20(6):e70015.

PMID: 39641325 PMC: 11745543. DOI: 10.1002/rcs.70015.

A Comprehensive Review of Piezoelectric Ultrasonic Motors: Classifications, Characterization, Fabrication, Applications, and Future Challenges.

Naz S, Xu T Micromachines (Basel). 2024; 15(9).

PMID: 39337830 PMC: 11433840. DOI: 10.3390/mi15091170.

Effect of Magnetic Resonance Imaging on the Motion Accuracy of Magnetic Resonance Imaging-compatible Focused Ultrasound Robotic System.

Antoniou A, Evripidou N, Chrysanthou A, Georgiou L, Ioannides C, Spanoudes K J Med Phys. 2024; 49(2):203-212.

PMID: 39131431 PMC: 11309133. DOI: 10.4103/jmp.jmp_7_24.

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