The Cutting Edge of Archaeal Transcription

Overview

Journal Emerg Top Life Sci

Specialty Biology

Date 2021 Feb 2

PMID 33525828

Citations 15

Authors

Thomas Fouqueau

Fabian Blombach

Gwenny Cackett

Alice E Carty

Dorota M Matelska

Sapir Ofer

Simona Pilotto

Duy Khanh Phung

Finn Werner

Affiliations

Soon will be listed here.

Abstract

The archaeal RNA polymerase (RNAP) is a double-psi β-barrel enzyme closely related to eukaryotic RNAPII in terms of subunit composition and architecture, promoter elements and basal transcription factors required for the initiation and elongation phase of transcription. Understanding archaeal transcription is, therefore, key to delineate the universally conserved fundamental mechanisms of transcription as well as the evolution of the archaeo-eukaryotic transcription machineries. The dynamic interplay between RNAP subunits, transcription factors and nucleic acids dictates the activity of RNAP and ultimately gene expression. This review focusses on recent progress in our understanding of (i) the structure, function and molecular mechanisms of known and less characterized factors including Elf1 (Elongation factor 1), NusA (N-utilization substance A), TFS4, RIP and Eta, and (ii) their evolution and phylogenetic distribution across the expanding tree of Archaea.

Citing Articles

Chromatin and gene regulation in archaea.

Blombach F, Werner F Mol Microbiol. 2024; 123(3):218-231.

PMID: 39096085 PMC: 11894787. DOI: 10.1111/mmi.15302.

Structure of the recombinant RNA polymerase from African Swine Fever Virus.

Pilotto S, Sykora M, Cackett G, Dulson C, Werner F Nat Commun. 2024; 15(1):1606.

PMID: 38383525 PMC: 10881513. DOI: 10.1038/s41467-024-45842-7.

An Initial Proteomic Analysis of Biogas-Related Metabolism of Consortia in Sediments from the Santiago River, México.

Barrera-Rojas J, Gurubel-Tun K, Rios-Castro E, Lopez-Mendez M, Sulbaran-Rangel B Microorganisms. 2023; 11(7).

PMID: 37512813 PMC: 10384328. DOI: 10.3390/microorganisms11071640.

Robust regulation of transcription pausing in by the ubiquitous elongation factor NusG.

Yakhnin A, Bubunenko M, Mandell Z, Lubkowska L, Husher S, Babitzke P Proc Natl Acad Sci U S A. 2023; 120(24):e2221114120.

PMID: 37276387 PMC: 10268239. DOI: 10.1073/pnas.2221114120.

Explainable artificial intelligence as a reliable annotator of archaeal promoter regions.

Martinez G, Perez-Rueda E, Kumar A, Sarkar S, de Avila E Silva S Sci Rep. 2023; 13(1):1763.

PMID: 36720898 PMC: 9889792. DOI: 10.1038/s41598-023-28571-7.

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