Unfolded Protein Response in Colorectal Cancer

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2021 Jan 30

PMID 33514437

Citations 28

Authors

Jingjing Huang

Huayang Pan

Jinge Wang

Tong Wang

Xiaoyan Huo

Yong Ma

Zhaoyang Lu

Bei Sun

Hongchi Jiang

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal cancer. The UPR has three canonical endoplasmic reticulum (ER) transmembrane protein sensors: inositol requiring kinase 1 (IRE1), pancreatic ER eIF2α kinase (PERK), and activating transcription factor 6 (ATF6). Each of the three pathways is closely associated with CRC development. The three pathways are relatively independent as well as interrelated. Under ER stress, the activated UPR boosts the protein folding capacity to maximize cell adaptation and survival, whereas sustained or excessive ER triggers cell apoptosis conversely. The UPR involves different stages of CRC pathogenesis, promotes or hinders the progression of CRC, and will pave the way for novel therapeutic and diagnostic approaches. Meanwhile, the correlation between different signal branches in UPR and the switch between the adaptation and apoptosis pathways still need to be further investigated in the future.

Citing Articles

Preliminary analysis of the role of small hepatitis B surface proteins mutations in the pathogenesis of occult hepatitis B infection via the endoplasmic reticulum stress-induced UPR-ERAD pathway.

Huang C, Zhang H, Wang J, Li J, Liu Q, Zong Q Open Life Sci. 2025; 20(1):20220951.

PMID: 39926475 PMC: 11806202. DOI: 10.1515/biol-2022-0951.

Unfolded protein response during the progression of colorectal carcinogenesis.

Augusto Sobrinho C, Almeida A, Grigolo M, Selzler M, Abreu A, Fagundes L Acta Cir Bras. 2025; 40():e400725.

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Recruitment of USP10 by GCS1 to deubiquitinate GRP78 promotes the progression of colorectal cancer via alleviating endoplasmic reticulum stress.

Chen Y, Shen H, Wang Z, Huang C, Zhang H, Shao Y J Exp Clin Cancer Res. 2024; 43(1):261.

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