Endoplasmic Reticulum Stress in Malignancy

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2014 May 15

PMID 24823636

Citations 245

Authors

Hanna J Clarke

Joseph E Chambers

Elizabeth Liniker

Stefan J Marciniak

Affiliations

Soon will be listed here.

Abstract

The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.

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