Ectopic Insulin Secretion by a Large-cell Neuroendocrine Carcinoma of the Cervix

Overview

Journal Clin Case Rep

Date 2021 Jan 28

PMID 33505694

Citations 5

Authors

Mawson Wang

Quinlan Vasey

Winny Varikatt

Mark McLean

Affiliations

Soon will be listed here.

Abstract

In patients presenting with hyperinsulinemic hypoglycemia with a nonpancreatic neuroendocrine tumor, the diagnosis of an ectopic insulin-secreting tumor should be considered, and investigated further with confirmatory insulin staining.

Citing Articles

Large cell neuroendocrine carcinoma of the cervix: a case report.

Li C, Wu M, Zhang W, Jiang X, Zhang L, Wang G Front Oncol. 2024; 14:1419710.

PMID: 39114303 PMC: 11303192. DOI: 10.3389/fonc.2024.1419710.

Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review.

Xie M, Li Y, Chen H, Jiang Q, Xiong H Oncol Lett. 2024; 28(1):313.

PMID: 38807671 PMC: 11130609. DOI: 10.3892/ol.2024.14446.

Ectopic insulinoma: a systematic review.

Guerrero-Perez F, Vilarrasa N, Huanuco L, Busquets J, Secanella L, Vercher-Conejero J Rev Endocr Metab Disord. 2023; 24(6):1135-1146.

PMID: 37434098 DOI: 10.1007/s11154-023-09824-2.

Case presentation of 8-year follow up of recurrent malignant duodenal Insulinoma and lymph node metastases and literature review of malignant Insulinoma management.

Walker M, Shenoy V, Metz D, Stanley C, Fraker D, Chandrasekhara V BMC Endocr Disord. 2022; 22(1):310.

PMID: 36494838 PMC: 9733155. DOI: 10.1186/s12902-022-01219-9.

Ectopic insulin secretion by a large-cell neuroendocrine carcinoma of the cervix.

Wang M, Vasey Q, Varikatt W, McLean M Clin Case Rep. 2021; 9(1):482-486.

PMID: 33505694 PMC: 7813122. DOI: 10.1002/ccr3.3562.

References

Gilks C, Young R, Gersell D, Clement P . Large cell neuroendocrine [corrected] carcinoma of the uterine cervix: a clinicopathologic study of 12 cases. Am J Surg Pathol. 1997; 21(8):905-14. DOI: 10.1097/00000478-199708000-00004. View

Wang M, Vasey Q, Varikatt W, McLean M . Ectopic insulin secretion by a large-cell neuroendocrine carcinoma of the cervix. Clin Case Rep. 2021; 9(1):482-486. PMC: 7813122. DOI: 10.1002/ccr3.3562. View

Rindi G, Klimstra D, Abedi-Ardekani B, Asa S, Bosman F, Brambilla E . A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol. 2018; 31(12):1770-1786. PMC: 6265262. DOI: 10.1038/s41379-018-0110-y. View

Cryer P, Axelrod L, Grossman A, Heller S, Montori V, Seaquist E . Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2008; 94(3):709-28. DOI: 10.1210/jc.2008-1410. View

Mathur A, Gorden P, Libutti S . Insulinoma. Surg Clin North Am. 2009; 89(5):1105-21. PMC: 3470467. DOI: 10.1016/j.suc.2009.06.009. View

Ramkumar S, Dhingra A, Jyotsna V, Ganie M, Das C, Seth A . Ectopic insulin secreting neuroendocrine tumor of kidney with recurrent hypoglycemia: a diagnostic dilemma. BMC Endocr Disord. 2014; 14:36. PMC: 4046058. DOI: 10.1186/1472-6823-14-36. View

Gadducci A, Carinelli S, Aletti G . Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists. Gynecol Oncol. 2017; 144(3):637-646. DOI: 10.1016/j.ygyno.2016.12.003. View

Jurgensen C, Schuppan D, Neser F, Ernstberger J, Junghans U, Stolzel U . EUS-guided alcohol ablation of an insulinoma. Gastrointest Endosc. 2006; 63(7):1059-62. DOI: 10.1016/j.gie.2005.10.034. View

Bhatla N, Berek J, Cuello Fredes M, Denny L, Grenman S, Karunaratne K . Revised FIGO staging for carcinoma of the cervix uteri. Int J Gynaecol Obstet. 2019; 145(1):129-135. DOI: 10.1002/ijgo.12749. View

10.

Kiang D, BAUER G, Kennedy B . Immunoassayable insulin in carcinoma of the cervix associated with hypoglycemia. Cancer. 1973; 31(4):801-5. DOI: 10.1002/1097-0142(197304)31:4<801::aid-cncr2820310407>3.0.co;2-j. View

11.

Chen J, Macdonald O, Gaffney D . Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. Obstet Gynecol. 2008; 111(6):1394-402. DOI: 10.1097/AOG.0b013e318173570b. View

12.

Seckl M, Mulholland P, Bishop A, Teale J, Hales C, Glaser M . Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. N Engl J Med. 1999; 341(10):733-6. DOI: 10.1056/NEJM199909023411004. View

13.

Iglesias P, Diez J . Management of endocrine disease: a clinical update on tumor-induced hypoglycemia. Eur J Endocrinol. 2014; 170(4):R147-57. DOI: 10.1530/EJE-13-1012. View

14.

Limmer S, Huppert P, Juette V, Lenhart A, Welte M, Wietholtz H . Radiofrequency ablation of solitary pancreatic insulinoma in a patient with episodes of severe hypoglycemia. Eur J Gastroenterol Hepatol. 2009; 21(9):1097-101. DOI: 10.1097/meg.0b013e328323d70e. View