Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2021 Jan 28

PMID 33504009

Citations 9

Authors

Alperen Abaci

Christina Gedeon

Anna Kuna

Murat Guvendiren

Affiliations

Soon will be listed here.

Abstract

Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared to tablets manufactured using conventional approaches. Despite these advantages, AM has not yet become the mainstream manufacturing approach for fabrication of oral solid dosage forms mainly due to limitations of AM technologies and lack of diverse printable drug formulations. In this review, AM of oral tablets are summarized with respect to AM technology. A detailed review of AM methods and materials used for the AM of oral tablets is presented. This article also reviews the challenges in AM of pharmaceutical formulations and potential strategies to overcome these challenges.

Citing Articles

Fabrication of Polypill Pharmaceutical Dosage Forms Using Fused Deposition Modeling 3D Printing: A Systematic Review.

Yasin H, Al-Tabakha M, Chan S Pharmaceutics. 2024; 16(10).

PMID: 39458614 PMC: 11510916. DOI: 10.3390/pharmaceutics16101285.

An Additive Manufacturing MicroFactory: Overcoming Brittle Material Failure and Improving Product Performance through Tablet Micro-Structure Control for an Immediate Release Dose Form.

Prasad E, Robertson J, Halbert G Polymers (Basel). 2024; 16(18).

PMID: 39339030 PMC: 11435212. DOI: 10.3390/polym16182566.

A Bibliometric Analysis of 3D Printing in Personalized Medicine Research from 2012 to 2022.

Xue A, Li W, Tian W, Zheng M, Shen L, Hong Y Pharmaceuticals (Basel). 2023; 16(11).

PMID: 38004387 PMC: 10675621. DOI: 10.3390/ph16111521.

Dose Titration of Solid Dosage Forms via FDM 3D-Printed Mini-Tablets.

Gorkem Buyukgoz G, Kossor C, Ji S, Guvendiren M, Dave R Pharmaceutics. 2022; 14(11).

PMID: 36365124 PMC: 9695869. DOI: 10.3390/pharmaceutics14112305.

Material extrusion additive manufacturing of dense pastes consisting of macroscopic particles.

Marnot A, Dobbs A, Brettmann B MRS Commun. 2022; 12(5):483-494.

PMID: 36312900 PMC: 9596591. DOI: 10.1557/s43579-022-00209-1.

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