The Host Immune Response to /

Overview

Journal J Fungi (Basel)

Date 2021 Jan 27

PMID 33499053

Citations 5

Authors

Idoia Buldain

Leire Martin-Souto

Aitziber Antoran

Maialen Areitio

Leire Aparicio-Fernandez

Aitor Rementeria

Fernando L Hernando

Andoni Ramirez-Garcia

Affiliations

Soon will be listed here.

Abstract

Infections caused by the opportunistic pathogens / are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against these fungi, since an understanding of the mechanisms involved is of great interest in developing more effective strategies against them. / cell wall components, including peptidorhamnomannans (PRMs), α-glucans and glucosylceramides, are important immune response activators following their recognition by TLR2, TLR4 and Dectin-1 and through receptors that are yet unknown. After recognition, cytokine synthesis and antifungal activity of different phagocytes and epithelial cells is species-specific, highlighting the poor response by microglial cells against . Moreover, a great number of / antigens have been identified, most notably catalase, PRM and Hsp70 for their potential medical applicability. Against host immune response, these fungi contain evasion mechanisms, inducing host non-protective response, masking fungal molecular patterns, destructing host defense proteins and decreasing oxidative killing. In conclusion, although many advances have been made, many aspects remain to be elucidated and more research is necessary to shed light on the immune response to /.

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