» Articles » PMID: 33498837

Fractalkine, SICAM-1 and Kynurenine Pathway in Restrictive Anorexia Nervosa-Exploratory Study

Overview
Journal Nutrients
Date 2021 Jan 27
PMID 33498837
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

The link between the kynurenine pathway and immunomodulatory molecules-fractalkine and soluble intercellular adhesion molecule-1 (sICAM-1)-in anorexia nervosa (AN) remains unknown. Fractalkine, sICAM-1, tryptophan (TRP), kynurenine (KYN), neuroprotective kynurenic acid (KYNA), neurotoxic 3-OH-kynurenine (3-OH-KYN), and the expression of mRNA for kynurenine aminotransferases () were studied in 20 female patients with restrictive AN (mostly drug-free, all during first episode of the disease) and in 24 controls. In AN, serum fractalkine, but not sICAM-1, KYNA, KYN, TRP or 3-OH-KYN, was higher; ratios TRP/KYN, KYN/KYNA, KYN/3-OH-KYN and KYNA/3-OH-KYN were unaltered. The expression of the gene encoding , but not of genes encoding and (measured in blood mononuclear cells), was higher in patients with AN. In AN, fractalkine positively correlated with TRP, while sICAM-1 was negatively associated with 3-OH-KYN and positively linked with the ratio KYN/3-OH-KYN. Furthermore, TRP and fractalkine were negatively associated with the body mass index (BMI) in AN. Expression of , and did not correlate with fractalkine, sICAM-1 or BMI, either in AN or control. Increased fractalkine may be an independent factor associated with the restrictive type of AN. Excessive physical activity probably underlies increased expression of observed among enrolled patients. Further, longitudinal studies on a larger cohort of patients should be aimed to clarify the contribution of fractalkine and to the pathogenesis of AN.

Citing Articles

Inclusion of the severe and enduring anorexia nervosa phenotype in genetics research: a scoping review.

Ramsay S, Allison K, Temples H, Boccuto L, Sarasua S J Eat Disord. 2024; 12(1):53.

PMID: 38685102 PMC: 11059621. DOI: 10.1186/s40337-024-01009-9.


New Perspective on Anorexia Nervosa: Tryptophan-Kynurenine Pathway Hypothesis.

Alberts C, Owe-Larsson M, Urbanska E Nutrients. 2023; 15(4).

PMID: 36839388 PMC: 9967350. DOI: 10.3390/nu15041030.


DNA Methylation Levels and Serum Kynurenine/Tryptophan Ratio in Eating Disorders: A Possible Link with Psychopathological Traits?.

Franzago M, Orecchini E, Porreca A, Mondanelli G, Orabona C, Ragione L Nutrients. 2023; 15(2).

PMID: 36678277 PMC: 9866524. DOI: 10.3390/nu15020406.


Periphery-Brain Interactions and Leptin in the Regulation of Whole-Body Energy Metabolism.

Hankir M, Bruneau Jr M Nutrients. 2022; 14(8).

PMID: 35458156 PMC: 9027188. DOI: 10.3390/nu14081594.

References
1.
Rassoulpour A, Wu H, Ferre S, Schwarcz R . Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum. J Neurochem. 2005; 93(3):762-5. DOI: 10.1111/j.1471-4159.2005.03134.x. View

2.
Guidetti P, Okuno E, Schwarcz R . Characterization of rat brain kynurenine aminotransferases I and II. J Neurosci Res. 1997; 50(3):457-65. DOI: 10.1002/(SICI)1097-4547(19971101)50:3<457::AID-JNR12>3.0.CO;2-3. View

3.
Rossetti A, Papp M, Gruca P, Paladini M, Racagni G, Riva M . Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention. Pharmacol Res. 2015; 103:1-12. DOI: 10.1016/j.phrs.2015.10.022. View

4.
Zhang S, Tang H, Gong C, Liu J, Chen J . Assessment of serum CX3CL1/fractalkine level in Han Chinese girls with anorexia nervosa and its correlation with nutritional status: a preliminary cross-sectional study. J Investig Med. 2016; 65(2):333-337. DOI: 10.1136/jim-2016-000209. View

5.
Myint A, Kim Y, Verkerk R, Scharpe S, Steinbusch H, Leonard B . Kynurenine pathway in major depression: evidence of impaired neuroprotection. J Affect Disord. 2006; 98(1-2):143-51. DOI: 10.1016/j.jad.2006.07.013. View