Clinical Efficacy of Mesenchymal Stem Cells in Bone Regeneration in Oral Implantology. Systematic Review and Meta-Analysis

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2021 Jan 26

PMID 33494139

Citations 3

Authors

Sonia Egido-Moreno

Joan Valls-Roca-Umbert

Juan Manuel Cespedes-Sanchez

Jose Lopez-Lopez

Eugenio Velasco-Ortega

Affiliations

Soon will be listed here.

Abstract

In bone regeneration, obtaining a vital bone as similar as possible to native bone is sought. This review aimed to evaluate the efficacy of stem cells in maxillary bone regeneration for implant rehabilitation and to review the different techniques for obtaining and processing these cells. A systematic review and meta-analysis were performed using the Pubmed/Medline (NCBI), Cochrane, Scielo, and Scopus databases, without restriction on the publication date. The following Mesh terms were used, combined by the Boolean operator "AND": "dental implants" AND "stem cells" AND "bioengineering". Applying inclusion and exclusion criteria, five articles were obtained and three were added after manual search. The results from the meta-analysis (18 patients) did not provide significant differences despite the percentage of bone formed in the maxillary sinus, favoring the stem cell group, and the analysis of the percentage of residual Bio-Oss showed results favoring the control group. Stem cell regeneration usually shows positive vascular and viable bone formation. In conclusion, using mesenchymal stem cells in bone regeneration provides benefits in the quality of bone, similar or even superior to autologous bone, all this through a minimally invasive procedure.

Citing Articles

Preconditioning Methods to Improve Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Bone Regeneration-A Systematic Review.

Hertel F, Silva A, Sabino A, Valente F, Reis E Biology (Basel). 2022; 11(5).

PMID: 35625461 PMC: 9138769. DOI: 10.3390/biology11050733.

Posology and Serum-/Xeno-Free Engineered Adipose Stromal Cells Cell Sheets.

Ochiai J, Villanueva L, Niihara H, Niihara Y, Oliva J Front Cell Dev Biol. 2022; 10:873603.

PMID: 35557946 PMC: 9086846. DOI: 10.3389/fcell.2022.873603.

Clinical Outcome and 8-Year Follow-Up of Alveolar Bone Tissue Engineering for Severely Atrophic Alveolar Bone Using Autologous Bone Marrow Stromal Cells with Platelet-Rich Plasma and β-Tricalcium Phosphate Granules.

Asahina I, Kagami H, Agata H, Honda M, Sumita Y, Inoue M J Clin Med. 2021; 10(22).

PMID: 34830513 PMC: 8623501. DOI: 10.3390/jcm10225231.

References

Berber I, Erkurt M, Kuku I, Kaya E, Kutlu R, Koroglu M . An unexpected complication of bone marrow aspiration and trephine biopsy: arteriovenous fistula. Med Princ Pract. 2014; 23(4):380-3. PMC: 5586889. DOI: 10.1159/000358173. View

Paz A, Maghaireh H, Mangano F . Stem Cells in Dentistry: Types of Intra- and Extraoral Tissue-Derived Stem Cells and Clinical Applications. Stem Cells Int. 2018; 2018:4313610. PMC: 6051054. DOI: 10.1155/2018/4313610. View

Soltan M, Smiler D, Gailani F . A new "platinum" standard for bone grafting: autogenous stem cells. Implant Dent. 2005; 14(4):322-5. DOI: 10.1097/01.id.0000190419.04705.ef. View

Branemark P . Osseointegration and its experimental background. J Prosthet Dent. 1983; 50(3):399-410. DOI: 10.1016/s0022-3913(83)80101-2. View

Bae M, Kim J, Lee J, Heo D, Yang D, Kim J . ZrO₂ surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis in dentistry. Carbohydr Polym. 2012; 92(1):167-75. DOI: 10.1016/j.carbpol.2012.09.044. View

Pittenger M, Mackay A, Beck S, Jaiswal R, Douglas R, Mosca J . Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284(5411):143-7. DOI: 10.1126/science.284.5411.143. View

Kaigler D, Avila-Ortiz G, Travan S, Taut A, Padial-Molina M, Rudek I . Bone Engineering of Maxillary Sinus Bone Deficiencies Using Enriched CD90+ Stem Cell Therapy: A Randomized Clinical Trial. J Bone Miner Res. 2015; 30(7):1206-16. DOI: 10.1002/jbmr.2464. View

Aslan H, Zilberman Y, Kandel L, Liebergall M, Oskouian R, Gazit D . Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells. Stem Cells. 2006; 24(7):1728-37. DOI: 10.1634/stemcells.2005-0546. View

Genova T, Roato I, Carossa M, Motta C, Cavagnetto D, Mussano F . Advances on Bone Substitutes through 3D Bioprinting. Int J Mol Sci. 2020; 21(19). PMC: 7582371. DOI: 10.3390/ijms21197012. View

10.

Gjerde C, Mustafa K, Hellem S, Rojewski M, Gjengedal H, Yassin M . Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. Stem Cell Res Ther. 2018; 9(1):213. PMC: 6085689. DOI: 10.1186/s13287-018-0951-9. View

11.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

12.

Ueda M, Yamada Y, Kagami H, Hibi H . Injectable bone applied for ridge augmentation and dental implant placement: human progress study. Implant Dent. 2008; 17(1):82-90. DOI: 10.1097/ID.0b013e31815cd591. View

13.

Chavda S, Levin L . Human Studies of Vertical and Horizontal Alveolar Ridge Augmentation Comparing Different Types of Bone Graft Materials: A Systematic Review. J Oral Implantol. 2017; 44(1):74-84. DOI: 10.1563/aaid-joi-D-17-00053. View

14.

Rickert D, Sauerbier S, Nagursky H, Menne D, Vissink A, Raghoebar G . Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial. Clin Oral Implants Res. 2010; 22(3):251-8. DOI: 10.1111/j.1600-0501.2010.01981.x. View

15.

Henry P . Tooth loss and implant replacement. Aust Dent J. 2000; 45(3):150-72. DOI: 10.1111/j.1834-7819.2000.tb00552.x. View

16.

Jadad A, Moore R, Carroll D, Jenkinson C, Reynolds D, Gavaghan D . Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996; 17(1):1-12. DOI: 10.1016/0197-2456(95)00134-4. View

17.

Wildburger A, Payer M, Jakse N, Strunk D, Etchard-Liechtenstein N, Sauerbier S . Impact of autogenous concentrated bone marrow aspirate on bone regeneration after sinus floor augmentation with a bovine bone substitute--a split-mouth pilot study. Clin Oral Implants Res. 2013; 25(10):1175-81. DOI: 10.1111/clr.12228. View

18.

Dimitriou R, Mataliotakis G, Angoules A, Kanakaris N, Giannoudis P . Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review. Injury. 2011; 42 Suppl 2:S3-15. DOI: 10.1016/j.injury.2011.06.015. View

19.

Sargozaie N, Moeintaghavi A, Shojaie H . Comparing the Quality of Life of Patients Requesting Dental Implants Before and After Implant. Open Dent J. 2017; 11:485-491. PMC: 5646019. DOI: 10.2174/1874210601711010485. View

20.

Chahla J, Mannava S, Cinque M, Geeslin A, Codina D, LaPrade R . Bone Marrow Aspirate Concentrate Harvesting and Processing Technique. Arthrosc Tech. 2017; 6(2):e441-e445. PMC: 5443590. DOI: 10.1016/j.eats.2016.10.024. View