Embryo Genetics

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2021 Jan 22

PMID 33477974

Citations 5

Authors

Carmen Rubio

Carlos Simon

Affiliations

Soon will be listed here.

Abstract

Advances in embryo and reproductive genetics have influenced clinical approaches to overcome infertility. Since the 1990s, many attempts have been made to decipher the genetic causes of infertility and to understand the role of chromosome aneuploidies in embryo potential. At the embryo stage, preimplantation genetic testing for chromosomal abnormalities and genetic disorders has offered many couples the opportunity to have healthy offspring. Recently, the application of new technologies has resulted in more comprehensive and accurate diagnoses of chromosomal abnormalities and genetic conditions to improve clinical outcome. In this Special Issue, we include a collection of reviews and original articles covering many aspects of embryo diagnosis, genome editing, and maternal-embryo cross-communication during the implantation process.

Citing Articles

Introducing an Antenatal Care Electronic Health System for Low and Middle Income Countries: A Cross-Sectional Study on 1217 Iranian Pregnant Women.

Zamaninasab H, Heidarpanah A, Ghaemi M J Family Reprod Health. 2024; 17(4):216-228.

PMID: 38807620 PMC: 11128729. DOI: 10.18502/jfrh.v17i4.14593.

Genetic counseling for pre-implantation genetic testing of monogenic disorders (PGT-M).

Parikh F, Athalye A, Madon P, Khandeparkar M, Naik D, Sanap R Front Reprod Health. 2024; 5:1213546.

PMID: 38162012 PMC: 10755023. DOI: 10.3389/frph.2023.1213546.

Metabolic plasticity sustains the robustness of Caenorhabditis elegans embryogenesis.

Chen S, Su X, Zhu J, Xiao L, Cong Y, Yang L EMBO Rep. 2023; 24(12):e57440.

PMID: 37885348 PMC: 10702823. DOI: 10.15252/embr.202357440.

Genetics Matters: Voyaging from the Past into the Future of Humanity and Sustainability.

Cheng A, Harikrishna J, Redwood C, Lit L, Nath S, Chua K Int J Mol Sci. 2022; 23(7).

PMID: 35409335 PMC: 8999725. DOI: 10.3390/ijms23073976.

Evolution and Utility of Preimplantation Genetic Testing for Monogenic Disorders in Assisted Reproduction - A Narrative Review.

Parikh F, Athalye A, Kulkarni D, Sanap R, Dhumal S, Warang D J Hum Reprod Sci. 2022; 14(4):329-339.

PMID: 35197677 PMC: 8812395. DOI: 10.4103/jhrs.jhrs_148_21.

References

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Mir Pardo P, Martinez-Conejero J, Martin J, Simon C, Cervero A . Combined Preimplantation Genetic Testing for Autosomal Dominant Polycystic Kidney Disease: Consequences for Embryos Available for Transfer. Genes (Basel). 2020; 11(6). PMC: 7349812. DOI: 10.3390/genes11060692. View

Rodrigo L, Clemente-Ciscar M, Campos-Galindo I, Peinado V, Simon C, Rubio C . Characteristics of the IVF Cycle that Contribute to the Incidence of Mosaicism. Genes (Basel). 2020; 11(10). PMC: 7600993. DOI: 10.3390/genes11101151. View

10.

Reddy P, Vilella F, Izpisua Belmonte J, Simon C . Use of Customizable Nucleases for Gene Editing and Other Novel Applications. Genes (Basel). 2020; 11(9). PMC: 7565838. DOI: 10.3390/genes11090976. View

11.

Garcia-Pascual C, Navarro-Sanchez L, Navarro R, Martinez L, Jimenez J, Rodrigo L . Optimized NGS Approach for Detection of Aneuploidies and Mosaicism in PGT-A and Imbalances in PGT-SR. Genes (Basel). 2020; 11(7). PMC: 7397276. DOI: 10.3390/genes11070724. View

12.

Simon B, Bolumar D, Amadoz A, Jimenez-Almazan J, Valbuena D, Vilella F . Identification and Characterization of Extracellular Vesicles and Its DNA Cargo Secreted During Murine Embryo Development. Genes (Basel). 2020; 11(2). PMC: 7074575. DOI: 10.3390/genes11020203. View