Dispensability of Tubulin Acetylation for 15-protofilament Microtubule Formation in the Mammalian Cochlea

Overview

Journal Cell Struct Funct

Specialty Cell Biology

Date 2021 Jan 21

PMID 33473065

Citations 1

Authors

Justine Renauld

Nicolas Thelen

Odile Bartholome

Brigitte Malgrange

Marc Thiry

Affiliations

Soon will be listed here.

Abstract

The development of hearing in mammals requires the formation and maturation of a highly organized and specialized epithelium known as the organ of Corti. This epithelium contains two types of cells, the sensory cells, which are the true receptors of auditory information, and the surrounding supporting cells, which are composed of a highly developed cytoskeleton essential to the architecture of the mature organ of Corti. The supporting cells are the only mammalian cells reported to contain the unusual 15-protofilament microtubules. In this paper, we show that 15-protofilament microtubules appear between the second and fourth day after birth in the pillar cells of the organ of Corti in mice. We also show that contrary to what has been described in the nematode worm Caenorhabiditis. elegans, microtubule acetylation is not essential for the formation of 15-protofilament microtubules in mice but is required for fine-tuning of their diameter.Key words: Acetylation, cytoskeleton, microtubule, inner ear, supporting cells.

Citing Articles

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