Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

Overview

Journal Life (Basel)

Specialty Biology

Date 2021 Jan 20

PMID 33467699

Citations 9

Authors

Mathilde Pruvost

Sarah Moyon

Affiliations

Soon will be listed here.

Abstract

Oligodendroglial cells are the myelinating cells of the central nervous system. While myelination is crucial to axonal activity and conduction, oligodendrocyte progenitor cells and oligodendrocytes have also been shown to be essential for neuronal support and metabolism. Thus, a tight regulation of oligodendroglial cell specification, proliferation, and myelination is required for correct neuronal connectivity and function. Here, we review the role of epigenetic modifications in oligodendroglial lineage cells. First, we briefly describe the epigenetic modalities of gene regulation, which are known to have a role in oligodendroglial cells. We then address how epigenetic enzymes and/or marks have been associated with oligodendrocyte progenitor specification, survival and proliferation, differentiation, and finally, myelination. We finally mention how environmental cues, in particular, neuronal signals, are translated into epigenetic modifications, which can directly influence oligodendroglial biology.

Citing Articles

Histone H4 acetylation differentially modulates proliferation in adult oligodendrocyte progenitors.

Dansu D, Selcen I, Sauma S, Prentice E, Huang D, Li M J Cell Biol. 2024; 223(11).

PMID: 39133301 PMC: 11318668. DOI: 10.1083/jcb.202308064.

Correction: Pruvost, M.; Moyon, S. Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination. 2021, , 62.

Pruvost M, Moyon S Life (Basel). 2024; 14(5).

PMID: 38792671 PMC: 11122379. DOI: 10.3390/life14050620.

EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor.

Sprinzen L, Garcia F, Mela A, Lei L, Upadhyayula P, Mahajan A Cells. 2024; 13(3.

PMID: 38334611 PMC: 10854521. DOI: 10.3390/cells13030219.

The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina.

Pruvost M, Patzig J, Yattah C, Selcen I, Hernandez M, Park H Cell Rep. 2023; 42(8):112848.

PMID: 37515770 PMC: 10600948. DOI: 10.1016/j.celrep.2023.112848.

The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration.

Fodder K, de Silva R, Warner T, Bettencourt C Acta Neuropathol Commun. 2023; 11(1):106.

PMID: 37386505 PMC: 10311741. DOI: 10.1186/s40478-023-01607-9.

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