The Landscape of MicroRNAs in βCell: Between Phenotype Maintenance and Protection

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jan 20

PMID 33466949

Citations 9

Authors

Giuseppina Emanuela Grieco

Noemi Brusco

Giada Licata

Daniela Fignani

Caterina Formichi

Laura Nigi

Guido Sebastiani

Francesco Dotta

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia mainly due to pancreatic β cell death and/or dysfunction, caused by several types of stress such as glucotoxicity, lipotoxicity and inflammation. Different patho-physiological mechanisms driving β cell response to these stresses are tightly regulated by microRNAs (miRNAs), a class of negative regulators of gene expression, involved in pathogenic mechanisms occurring in diabetes and in its complications. In this review, we aim to shed light on the most important miRNAs regulating the maintenance and the robustness of β cell identity, as well as on those miRNAs involved in the pathogenesis of the two main forms of diabetes mellitus, i.e., type 1 and type 2 diabetes. Additionally, we acknowledge that the understanding of miRNAs-regulated molecular mechanisms is fundamental in order to develop specific and effective strategies based on miRNAs as therapeutic targets, employing innovative molecules.

Citing Articles

The Parasite-Derived Peptide, FhHDM-1, Selectively Modulates miRNA Expression in -Cells to Prevent Apoptotic Pathways Induced by Proinflammatory Cytokines.

Camaya I, Hill M, Sais D, Tran N, OBrien B, Donnelly S J Diabetes Res. 2024; 2024:8555211.

PMID: 39022651 PMC: 11254460. DOI: 10.1155/2024/8555211.

Beta cell dedifferentiation in type 1 diabetes: sacrificing function for survival?.

Webster K, Mirmira R Front Endocrinol (Lausanne). 2024; 15:1427723.

PMID: 38904049 PMC: 11187278. DOI: 10.3389/fendo.2024.1427723.

Text mining-based identification of promising miRNA biomarkers for diabetes mellitus.

Li X, Dai A, Tran R, Wang J Front Endocrinol (Lausanne). 2023; 14:1195145.

PMID: 37560309 PMC: 10407569. DOI: 10.3389/fendo.2023.1195145.

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life.

Melnik B, Schmitz G Int J Mol Sci. 2022; 23(19).

PMID: 36232796 PMC: 9569743. DOI: 10.3390/ijms231911503.

Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation.

Grieco G, Brusco N, Fignani D, Nigi L, Formichi C, Licata G Cell Death Discov. 2022; 8(1):340.

PMID: 35906204 PMC: 9338237. DOI: 10.1038/s41420-022-01142-x.

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