Guido Sebastiani
Overview
Explore the profile of Guido Sebastiani including associated specialties, affiliations and a list of published articles.
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Articles
59
Citations
1652
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Recent Articles
1.
Auddino S, Aiello E, Grieco G, Dotta F, Sebastiani G
Trends Endocrinol Metab
. 2024 Nov;
PMID: 39532586
MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression post-transcriptionally and influence numerous biological processes. Aberrant miRNA expression is linked to diseases such as diabetes mellitus; indeed, miRNAs regulate...
2.
Almagro Armenteros J, Brorsson C, Johansen C, Banasik K, Mazzoni G, Moulder R, et al.
Diabetes Metab Res Rev
. 2024 Jul;
40(5):e3833.
PMID: 38961656
Aims: Heterogeneity in the rate of β-cell loss in newly diagnosed type 1 diabetes patients is poorly understood and creates a barrier to designing and interpreting disease-modifying clinical trials. Integrative...
3.
Sebastiani G, Grieco G, Bruttini M, Auddino S, Mori A, Toniolli M, et al.
Cell Rep Med
. 2024 Jun;
5(6):101591.
PMID: 38838677
Circulating microRNAs (miRNAs) are linked to the onset and progression of type 1 diabetes mellitus (T1DM), thus representing potential disease biomarkers. In this study, we employed a multiplatform sequencing approach...
4.
Sajiir H, Wong K, Muller A, Keshvari S, Burr L, Aiello E, et al.
Nat Commun
. 2024 May;
15(1):4527.
PMID: 38811550
The IL-22RA1 receptor is highly expressed in the pancreas, and exogenous IL-22 has been shown to reduce endoplasmic reticulum and oxidative stress in human pancreatic islets and promote secretion of...
5.
Sassi G, Licata G, Ventriglia G, Wouters A, Lemaitre P, Seurinck R, et al.
Diabetes
. 2023 Jul;
72(10):1470-1482.
PMID: 37494666
Article Highlights: Low-dose anti-CD3 combined with oral gavage of genetically modified Lactococcus lactis bacteria secreting human proinsulin and IL-10 holds great promise to arrest autoimmune type 1 diabetes, but the...
6.
Fignani D, Pedace E, Licata G, Grieco G, Aiello E, De Luca C, et al.
Diabetes Metab Res Rev
. 2023 Jul;
39(8):e3696.
PMID: 37466955
Aims: Angiotensin I-converting enzyme type 2 (ACE2), a pivotal SARS-CoV-2 receptor, has been shown to be expressed in multiple cells, including human pancreatic beta-cells. A putative bidirectional relationship between SARS-CoV-2...
7.
Brusco N, Sebastiani G, Giuseppe G, Licata G, Grieco G, Fignani D, et al.
Diabetologia
. 2022 Oct;
66(2):354-366.
PMID: 36280617
Aims/hypothesis: Endoplasmic reticulum (ER) stress and beta cell dedifferentiation both play leading roles in impaired insulin secretion in overt type 2 diabetes. Whether and how these factors are related in...
8.
Grieco G, Brusco N, Fignani D, Nigi L, Formichi C, Licata G, et al.
Cell Death Discov
. 2022 Jul;
8(1):340.
PMID: 35906204
The loss of functional β-cell mass in type 2 diabetes (T2D) is associated with molecular events that include β-cell apoptosis, dysfunction and/or dedifferentiation. MicroRNA miR-184-3p has been shown to be...
9.
Tomasi M, Caproni E, Benedet M, Zanella I, Giorgetta S, Dalsass M, et al.
Front Oncol
. 2022 Jul;
12:912639.
PMID: 35847919
A growing body of evidence supports the notion that the gut microbiome plays an important role in cancer immunity. However, the underpinning mechanisms remain to be fully elucidated. One attractive...
10.
Shaba E, Vantaggiato L, Governini L, Haxhiu A, Sebastiani G, Fignani D, et al.
Proteomes
. 2022 Jun;
10(2).
PMID: 35645370
In the era of multi-omic sciences, dogma on singular cause-effect in physio-pathological processes is overcome and system biology approaches have been providing new perspectives to see through. In this context,...