Renoprotective Effects of Estrogen on Acute Kidney Injury: the Role of SIRT1

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2021 Jan 18

PMID 33458788

Citations 11

Authors

Fatemeh Darvishzadeh Mahani

Mohammad Khaksari

Alireza Raji-Amirhasani

Affiliations

Soon will be listed here.

Abstract

Acute kidney injury (AKI) is a common syndrome associated with high morbidity and mortality, despite progress in medical care. Many studies have shown that there are sex differences and different role of sex hormones particularly estrogens in kidney injury. In this regard, the incidence and rate of progression of kidney diseases are higher in men compared with women. These observations suggest that female sex hormone may be renoprotective. Silent information regulator 2 homolog 1 (SIRT1) is a histone deacetylase, which is implicated in multiple biologic processes in several organisms. In the kidneys, SIRT1 inhibits renal cell apoptosis, inflammation, and fibrosis. Studies have reported a link between SIRT1 and estrogen. In addition, SIRT1 regulates ERα expression and inhibition of SIRT1 activity suppresses ERα expression. This effect leads to inhibition of estrogen-responsive gene expression. In this text, we review the role of SIRT1 in mediating the protective effects of estrogen in the onset and progression of AKI.

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