The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury

Overview

Journal Front Pharmacol

Date 2021 Jul 5

PMID 34220520

Citations 8

Authors

Xun Zhou

Hui Chen

Yingfeng Shi

Xiaoyan Ma

Shougang Zhuang

Na Liu

Affiliations

Soon will be listed here.

Abstract

Acute kidney injury (AKI) is a common clinical complication with an incidence of up to 8-18% in hospitalized patients. AKI is also a complication of COVID-19 patients and is associated with an increased risk of death. In recent years, numerous studies have suggested that epigenetic regulation is critically involved in the pathophysiological process and prognosis of AKI. Histone acetylation, one of the epigenetic regulations, is negatively regulated by histone deacetylases (HDACs). Increasing evidence indicates that HDACs play an important role in the pathophysiological development of AKI by regulation of apoptosis, inflammation, oxidative stress, fibrosis, cell survival, autophagy, ATP production, and mitochondrial biogenesis (MB). In this review, we summarize and discuss the role and mechanism of HDACs in the pathogenesis of AKI.

Citing Articles

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Histone deacetylase expression following cisplatin-induced acute kidney injury in male and female mice.

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