A Pilot Study: Effectiveness of Local Injection of Autologous Platelet-rich Plasma in Treating Women with Stress Urinary Incontinence

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jan 16

PMID 33452330

Citations 16

Authors

Cheng-Yu Long

Kun-Ling Lin

Chin-Ru Shen

Chin-Ru Ker

Yi-Yin Liu

Zi-Xi Loo

Hui-Hua Hsiao

Yung-Chin Lee

Affiliations

Soon will be listed here.

Abstract

The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wall where mid-urethra locates. Self-reported questionnaires were used to measure pre-treatment, 1 month and 6 months post-treatment symptom severity. Secondary outcomes of sexual function and treatment effect sorted by age were analyzed with valid statistical methods. A-PRP is effective in relieving SUI symptoms at both 1 month and 6 months post-treatment without significant adverse reactions reported. It seems to have a trend that treatment success rate with cured and improved symptoms was slightly higher in the younger group, although it did not reach statistical significance (P = 0.07). No significant changes in sexual function before and after the treatment were reported by the patients. This pilot study is the first to report A-PRP treatment effect for SUI in women. The result suggested that A-PRP is a considerable treatment option for mild to moderate SUI cases. It also opens up further research opportunities for A-PRP's clinical applications.

Citing Articles

Clinical efficacy of intracavernous injection of platelet lysate for erectile dysfunction.

Chang Y, Chiang I, Chang H, Chen Y, Jeff Chueh S BMC Urol. 2024; 24(1):237.

PMID: 39472866 PMC: 11520801. DOI: 10.1186/s12894-024-01633-2.

Platelet-rich plasma for treatment of female stress urinary incontinence.

Pourebrahimi A, Khalili A, Behzadi S, Eftekhari B, Reyhani H, Larijani A Int Urol Nephrol. 2024; 57(2):313-321.

PMID: 39390198 DOI: 10.1007/s11255-024-04229-9.

Hybrid high and low molecular weight chains of hyaluronan for clitoral injection is an effective modality treatment for increasing female sexual satisfaction: an interventional, randomized-controlled parallel study.

Atef L, Mohammed G, Al-Dhubaibi M, Soliman M, Bahaj S, Saleh Y Sex Med. 2024; 12(5):qfae067.

PMID: 39360229 PMC: 11443283. DOI: 10.1093/sexmed/qfae067.

The impact of plasma-rich platelet injection to perianal sphincters on incontinence and quality of life in patients with rectal cancer after low anterior or intersphincteric resection: a prospective cohort study.

Haksal M, Akin M, Karagoz E, Kocak M, Korkut E, Shahhosseini R Tech Coloproctol. 2024; 28(1):109.

PMID: 39143419 PMC: 11324693. DOI: 10.1007/s10151-024-02989-1.

Regenerative Medicine in Urogynecology: Where We Are and Where We Want to Be.

Henderson T, Christman K, Alperin M Urogynecology (Phila). 2024; 30(5):519-527.

PMID: 38683203 PMC: 11342648. DOI: 10.1097/SPV.0000000000001461.

References

Bodner-Adler B, Hanzal E, Pablik E, Koelbl H, Bodner K . Management of vesicovaginal fistulas (VVFs) in women following benign gynaecologic surgery: A systematic review and meta-analysis. PLoS One. 2017; 12(2):e0171554. PMC: 5321457. DOI: 10.1371/journal.pone.0171554. View

Alves R, Grimalt R . A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification. Skin Appendage Disord. 2018; 4(1):18-24. PMC: 5806188. DOI: 10.1159/000477353. View

Chrysanthopoulou E, Pergialiotis V, Perrea D, Kourkoulis S, Verikokos C, Doumouchtsis S . Platelet rich plasma as a minimally invasive approach to uterine prolapse. Med Hypotheses. 2017; 104:97-100. DOI: 10.1016/j.mehy.2017.05.018. View

Nikolopoulos K, Pergialiotis V, Perrea D, Doumouchtsis S . Restoration of the pubourethral ligament with platelet rich plasma for the treatment of stress urinary incontinence. Med Hypotheses. 2016; 90:29-31. DOI: 10.1016/j.mehy.2016.02.019. View

Guevara-Alvarez A, Schmitt A, Russell R, Imhoff A, Buchmann S . Growth factor delivery vehicles for tendon injuries: Mesenchymal stem cells and Platelet Rich Plasma. Muscles Ligaments Tendons J. 2014; 4(3):378-85. PMC: 4241431. View

Lewi L, Liekens D, Heyns L, Poliard E, Beutels E, Deprest J . In vitro evaluation of the ability of platelet-rich plasma to seal an iatrogenic fetal membrane defect. Prenat Diagn. 2009; 29(6):620-5. DOI: 10.1002/pd.2249. View

Colombo G, Fanton V, Sosa D, Criado Scholz E, Lotti J, Aragona S . Use of platelet rich plasma in human infertility. J Biol Regul Homeost Agents. 2017; 31(2 Suppl. 2):179-182. View

Petros P, Ulmsten U . An integral theory of female urinary incontinence. Experimental and clinical considerations. Acta Obstet Gynecol Scand Suppl. 1990; 153:7-31. DOI: 10.1111/j.1600-0412.1990.tb08027.x. View

Fanning J, Murrain L, Flora R, Hutchings T, Johnson J, Fenton B . Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery. J Minim Invasive Gynecol. 2007; 14(5):633-7. DOI: 10.1016/j.jmig.2007.05.014. View

10.

Klovning A, Avery K, Sandvik H, Hunskaar S . Comparison of two questionnaires for assessing the severity of urinary incontinence: The ICIQ-UI SF versus the incontinence severity index. Neurourol Urodyn. 2009; 28(5):411-5. DOI: 10.1002/nau.20674. View

11.

White Y, Woods D, Takai Y, Ishihara O, Seki H, Tilly J . Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. Nat Med. 2012; 18(3):413-21. PMC: 3296965. DOI: 10.1038/nm.2669. View

12.

Moutray T, Evans J, Lois N, Armstrong D, Peto T, Azuara-Blanco A . Different lasers and techniques for proliferative diabetic retinopathy. Cochrane Database Syst Rev. 2018; 3:CD012314. PMC: 6494342. DOI: 10.1002/14651858.CD012314.pub2. View

13.

Hua X, Zeng Y, Zhang R, Wang H, Diao J, Zhang P . Using platelet-rich plasma for the treatment of symptomatic cervical ectopy. Int J Gynaecol Obstet. 2012; 119(1):26-9. DOI: 10.1016/j.ijgo.2012.05.029. View

14.

Kunkle C, Hallock J, Hu X, Blomquist J, Thung S, Werner E . Cost utility analysis of urethral bulking agents versus midurethral sling in stress urinary incontinence. Female Pelvic Med Reconstr Surg. 2015; 21(3):154-9. DOI: 10.1097/SPV.0000000000000173. View

15.

Behnia-Willison F, Pour N, Mohamadi B, Willison N, Rock M, Holten I . Use of Platelet-rich Plasma for Vulvovaginal Autoimmune Conditions Like Lichen Sclerosus. Plast Reconstr Surg Glob Open. 2016; 4(11):e1124. PMC: 5142493. DOI: 10.1097/GOX.0000000000001124. View

16.

Einarsson J, Jonsdottir K, Mandle R . Use of autologous platelet gel in female pelvic organ prolapse surgery: a feasibility study. J Minim Invasive Gynecol. 2009; 16(2):204-7. DOI: 10.1016/j.jmig.2008.12.012. View

17.

Capobianco G, Madonia M, Morelli S, Dessole F, DE Vita D, Cherchi P . Management of female stress urinary incontinence: A care pathway and update. Maturitas. 2018; 109:32-38. DOI: 10.1016/j.maturitas.2017.12.008. View

18.

Matz E, Pearlman A, Terlecki R . Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions. Investig Clin Urol. 2018; 59(1):61-65. PMC: 5754585. DOI: 10.4111/icu.2018.59.1.61. View

19.

Lin K, Chou S, Long C . Effect of Er:YAG Laser for Women with Stress Urinary Incontinence. Biomed Res Int. 2019; 2019:7915813. PMC: 6350556. DOI: 10.1155/2019/7915813. View

20.

Behnia-Willison F, Nguyen T, Norbury A, Mohamadi B, Salvatore S, Lam A . Promising impact of platelet rich plasma and carbon dioxide laser for stress urinary incontinence. Eur J Obstet Gynecol Reprod Biol X. 2020; 5:100099. PMC: 6994399. DOI: 10.1016/j.eurox.2019.100099. View