The Effect of Inflammation and Insulin Resistance on Lipid and Lipoprotein Responsiveness to Dietary Intervention

Overview

Journal Curr Dev Nutr

Specialty Nutritional Sciences

Date 2021 Jan 15

PMID 33447695

Citations 8

Authors

Kristina S Petersen

Kate J Bowen

Alyssa M Tindall

Valerie K Sullivan

Emily A Johnston

Jennifer A Fleming

Penny M Kris-Etherton

Affiliations

Soon will be listed here.

Abstract

Lipids and lipoproteins are major targets for cardiovascular disease (CVD) prevention. Findings from a limited number of clinical trials suggest diet-induced atherogenic lipoprotein lowering can be altered in the presence of chronic low-grade inflammation or insulin resistance. This review summarizes results from randomized controlled trials that have examined diet-induced changes in lipids/lipoproteins by inflammatory or insulin sensitivity status. In addition, mechanisms to explain these clinical observations are explored. Post hoc analyses of data from a limited number of randomized controlled trials suggest attenuation of diet-induced lipid/lipoprotein lowering in individuals with inflammation and/or insulin resistance. These findings are supported by experimental studies showing that inflammatory stimuli and hyperinsulinemia alter genes involved in endogenous cholesterol synthesis and cholesterol uptake, reduce cholesterol efflux, and increase fatty acid biosynthesis. Further a priori defined research is required to better characterize how chronic low-grade inflammation and insulin resistance modulate lipid and lipoprotein responsiveness to guide CVD risk reduction in individuals presenting with these phenotypes.

Citing Articles

Saturated fatty acids and total and CVD mortality in Norway: a prospective cohort study with up to 45 years of follow-up.

Arnesen E, Laake I, Veierod M, Retterstol K Br J Nutr. 2024; :1-13.

PMID: 39279644 PMC: 11499087. DOI: 10.1017/S0007114524001351.

Association of Lipoprotein and Apolipoprotein Ratios With Glycemic Levels in Individuals With Prediabetes: A Case-Control Study.

Salih S Cureus. 2024; 16(6):e63500.

PMID: 39081429 PMC: 11287781. DOI: 10.7759/cureus.63500.

Mapping the landscape of research on insulin resistance: a visualization analysis of randomized clinical trials.

Zyoud S J Health Popul Nutr. 2024; 43(1):6.

PMID: 38195616 PMC: 10777523. DOI: 10.1186/s41043-024-00497-4.

The circadian rhythm: an influential soundtrack in the diabetes story.

Hariri A, Mirian M, Zarrabi A, Kohandel M, Amini-Pozveh M, Aref A Front Endocrinol (Lausanne). 2023; 14:1156757.

PMID: 37441501 PMC: 10333930. DOI: 10.3389/fendo.2023.1156757.

Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease.

Perumalsamy S, Huri H, Abdullah B, Mazlan O, Wan Ahmad W, Vethakkan S Metabolites. 2023; 13(3).

PMID: 36984867 PMC: 10054456. DOI: 10.3390/metabo13030427.

References

Erlinger T, Miller 3rd E, Charleston J, Appel L . Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trial. Circulation. 2003; 108(2):150-4. DOI: 10.1161/01.CIR.0000080288.30567.86. View

Zeisel S . A Conceptual Framework for Studying and Investing in Precision Nutrition. Front Genet. 2019; 10:200. PMC: 6431609. DOI: 10.3389/fgene.2019.00200. View

Reaven G, Abbasi F, Bernhart S, Coulston A, Darnell B, Dashti N . Insulin resistance, dietary cholesterol, and cholesterol concentration in postmenopausal women. Metabolism. 2001; 50(5):594-7. DOI: 10.1053/meta.2001.22559. View

St-Onge M, Zhang S, Darnell B, Allison D . Baseline serum C-reactive protein is associated with lipid responses to low-fat and high-polyunsaturated fat diets. J Nutr. 2009; 139(4):680-3. PMC: 2666362. DOI: 10.3945/jn.108.098251. View

Galic S, Sachithanandan N, Kay T, Steinberg G . Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity. Biochem J. 2014; 461(2):177-88. DOI: 10.1042/BJ20140143. View

Vincent M, Allen B, Palacios O, Haber L, Maki K . Meta-regression analysis of the effects of dietary cholesterol intake on LDL and HDL cholesterol. Am J Clin Nutr. 2019; 109(1):7-16. DOI: 10.1093/ajcn/nqy273. View

Vaisar T, Tang C, Babenko I, Hutchins P, Wimberger J, Suffredini A . Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity. J Lipid Res. 2015; 56(8):1519-30. PMC: 4513993. DOI: 10.1194/jlr.M059089. View

McGillicuddy F, de la Llera Moya M, Hinkle C, Joshi M, Chiquoine E, Billheimer J . Inflammation impairs reverse cholesterol transport in vivo. Circulation. 2009; 119(8):1135-45. PMC: 4937877. DOI: 10.1161/CIRCULATIONAHA.108.810721. View

Liu X, Strable M, Ntambi J . Stearoyl CoA desaturase 1: role in cellular inflammation and stress. Adv Nutr. 2012; 2(1):15-22. PMC: 3042787. DOI: 10.3945/an.110.000125. View

10.

Hilpert K, Kris-Etherton P, West S . Lipid response to a low-fat diet with or without soy is modified by C-reactive protein status in moderately hypercholesterolemic adults. J Nutr. 2005; 135(5):1075-9. DOI: 10.1093/jn/135.5.1075. View

11.

Foufelle F, Ferre P . New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J. 2002; 366(Pt 2):377-91. PMC: 1222807. DOI: 10.1042/BJ20020430. View

12.

Ferguson J, Allayee H, Gerszten R, Ideraabdullah F, Kris-Etherton P, Ordovas J . Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2016; 9(3):291-313. PMC: 7829062. DOI: 10.1161/HCG.0000000000000030. View

13.

Emanuelli B, Peraldi P, Filloux C, Hilton D, Van Obberghen E . SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem. 2000; 275(21):15985-91. DOI: 10.1074/jbc.275.21.15985. View

14.

Khoury M, Iademarco M, Riley W . Precision Public Health for the Era of Precision Medicine. Am J Prev Med. 2015; 50(3):398-401. PMC: 4915347. DOI: 10.1016/j.amepre.2015.08.031. View

15.

Schenk S, Saberi M, Olefsky J . Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008; 118(9):2992-3002. PMC: 2522344. DOI: 10.1172/JCI34260. View

16.

Ueki K, Kondo T, Tseng Y, Kahn C . Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A. 2004; 101(28):10422-7. PMC: 478587. DOI: 10.1073/pnas.0402511101. View

17.

Antman E, Loscalzo J . Precision medicine in cardiology. Nat Rev Cardiol. 2016; 13(10):591-602. DOI: 10.1038/nrcardio.2016.101. View

18.

Xiao H, Sun Z, Zhang H, Zhang D . Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation. Pharmacol Rep. 2012; 64(4):889-95. DOI: 10.1016/s1734-1140(12)70883-6. View

19.

Lee B, Lee J . Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta. 2013; 1842(3):446-62. PMC: 3800253. DOI: 10.1016/j.bbadis.2013.05.017. View

20.

Knopp R, Retzlaff B, Fish B, Walden C, Wallick S, Anderson M . Effects of insulin resistance and obesity on lipoproteins and sensitivity to egg feeding. Arterioscler Thromb Vasc Biol. 2003; 23(8):1437-43. DOI: 10.1161/01.ATV.0000082461.77557.C7. View