Safety Assessment of Genetically Modified Rice Expressing Cry1Ab Protein in Sprague-Dawley Rats

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jan 14

PMID 33441963

Authors

Bahador Hajimohammadi

Gilda Eslami

Hengameh Zandi

Mohammad Hassan Ehrampoush

Azar Naimi

Maryam Derakhshan

Pegah Hedayat

Roozbeh Fallahi

Hossein Fallahzadeh

Mohammad Ebrahim Rezvani

Mahmoud Vakili

Seyed Mohammad Moshtaghioun

Seyyed Shamsadin Athari

Seyedeh Leili Asadi-Yousefabad

Saeedeh Sadat Hosseini

Mehrnoush Shirdeli

Salman Ahmadian

Shirin Mortazavi

Elahe Loni

Vahid Ajamein

Amin Ahmadi

Vahideh Askari

Affiliations

Soon will be listed here.

Abstract

Rice is considered one of the most important staple food crops. Genetically modified (GM) Bt rice, harbored cry1Ab gene expressing the insect-resistance protein has been developed to resistance to the insects. In this study, we assessed the safety of the GM Bt rice on Sprague-Dawley rats for 90 days. Totally, 120 rats in both sexes were used for three different diets, including 50% GM Bt rice, feeding with 50% rice, and standard feeding. Each 40 SD rats including 20 males and 20 females were considered as each diet. The clinical variables such as body weight and food consumption were measured and a range of clinical tests was examined, including hematology, serum chemistry parameters, urinalysis profile, thyroid, and sex hormone levels. Pathological assessments were also done. The results showed that the mean weekly feed utilization (%) had no significant difference among the studied groups. Also, blood biochemistry, hematological parameters, urine analysis, and hormonal levels had no significant differences among the groups. However, alanine aminotransferase was less in males versus female feeding with GM Bt rice. No histopathological changes were observed among the groups. In conclusion, this study demonstrated that GM Bt rice had no obvious adverse effects on rats' health.

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