Innovative Strategies in Tendon Tissue Engineering

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2021 Jan 14

PMID 33440840

Citations 23

Authors

Eleonora Bianchi

Marco Ruggeri

Silvia Rossi

Barbara Vigani

Dalila Miele

Maria Cristina Bonferoni

Giuseppina Sandri

Franca Ferrari

Affiliations

Soon will be listed here.

Abstract

The tendon is a highly aligned connective tissue that transmits force from muscle to bone. Each year, more than 32 million tendon injuries have been reported, in fact, tendinopathies represent at least 50% of all sports injuries, and their incidence rates have increased in recent decades due to the aging population. Current clinical grafts used in tendon treatment are subject to several restrictions and there is a significant demand for alternative engineered tissue. For this reason, innovative strategies need to be explored. Tendon replacement and regeneration are complex since scaffolds need to guarantee an adequate hierarchical structured morphology and mechanical properties to stand the load. Moreover, to guide cell proliferation and growth, scaffolds should provide a fibrous network that mimics the collagen arrangement of the extracellular matrix in the tendons. This review focuses on tendon repair and regeneration. Particular attention has been devoted to the innovative approaches in tissue engineering. Advanced manufacturing techniques, such as electrospinning, soft lithography, and three-dimensional (3D) printing, have been described. Furthermore, biological augmentation has been considered, as an emerging strategy with great therapeutic potential.

Citing Articles

Synthesis and use of thermoplastic polymers for tissue engineering purposes.

Bianchi E, Ruggeri M, Vigani B, Aguzzi C, Rossi S, Sandri G Int J Pharm X. 2025; 9():100313.

PMID: 39807177 PMC: 11729033. DOI: 10.1016/j.ijpx.2024.100313.

Regenerative medicine: Hydrogels and mesoporous silica nanoparticles.

Pablos J, Lozano D, Manzano M, Vallet-Regi M Mater Today Bio. 2024; 29:101342.

PMID: 39649249 PMC: 11625165. DOI: 10.1016/j.mtbio.2024.101342.

Understanding the effects of mineralization and structure on the mechanical properties of tendon-bone insertion using mesoscale computational modeling.

Yang Z, Gordon D, Chen Y, Li H, Wu Y, Meng Z J Mech Behav Biomed Mater. 2024; 160:106735.

PMID: 39288664 PMC: 11560707. DOI: 10.1016/j.jmbbm.2024.106735.

Anti-Inflammatory and Antioxidant Properties of a New Mixture of Vitamin C, Collagen Peptides, Resveratrol, and Astaxanthin in Tenocytes: Molecular Basis for Future Applications in Tendinopathies.

Marzagalli M, Battaglia S, Raimondi M, Fontana F, Cozzi M, Ranieri F Mediators Inflamm. 2024; 2024:5273198.

PMID: 39108992 PMC: 11303056. DOI: 10.1155/2024/5273198.

The Use of Extracellular Vesicles in Achilles Tendon Repair: A Systematic Review.

Kasula V, Padala V, Gupta N, Doyle D, Bagheri K, Anastasio A Biomedicines. 2024; 12(5).

PMID: 38790904 PMC: 11117955. DOI: 10.3390/biomedicines12050942.

References

Snedeker J, Foolen J . Tendon injury and repair - A perspective on the basic mechanisms of tendon disease and future clinical therapy. Acta Biomater. 2017; 63:18-36. DOI: 10.1016/j.actbio.2017.08.032. View

Ide J, Kikukawa K, Hirose J, Iyama K, Sakamoto H, Fujimoto T . The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon. J Shoulder Elbow Surg. 2009; 18(3):391-8. DOI: 10.1016/j.jse.2009.01.013. View

Babo P, Reis R, Gomes M . Periodontal tissue engineering: current strategies and the role of platelet rich hemoderivatives. J Mater Chem B. 2020; 5(20):3617-3628. DOI: 10.1039/c7tb00010c. View

Pajala A, Melkko J, Leppilahti J, Ohtonen P, Soini Y, Risteli J . Tenascin-C and type I and III collagen expression in total Achilles tendon rupture. An immunohistochemical study. Histol Histopathol. 2009; 24(10):1207-11. DOI: 10.14670/HH-24.1207. View

Lima M, Pirraco R, Sousa R, Neves N, Marques A, Bhattacharya M . Bottom-up approach to construct microfabricated multi-layer scaffolds for bone tissue engineering. Biomed Microdevices. 2013; 16(1):69-78. DOI: 10.1007/s10544-013-9806-4. View

Zumstein M, Jost B, Hempel J, Hodler J, Gerber C . The clinical and structural long-term results of open repair of massive tears of the rotator cuff. J Bone Joint Surg Am. 2008; 90(11):2423-31. DOI: 10.2106/JBJS.G.00677. View

Lim W, Liau L, Ng M, Chowdhury S, Law J . Current Progress in Tendon and Ligament Tissue Engineering. Tissue Eng Regen Med. 2019; 16(6):549-571. PMC: 6879704. DOI: 10.1007/s13770-019-00196-w. View

Sharma P, Maffulli N . Tendinopathy and tendon injury: the future. Disabil Rehabil. 2008; 30(20-22):1733-45. DOI: 10.1080/09638280701788274. View

Thorpe C, Birch H, Clegg P, Screen H . The role of the non-collagenous matrix in tendon function. Int J Exp Pathol. 2013; 94(4):248-59. PMC: 3721456. DOI: 10.1111/iep.12027. View

10.

Martineau I, Lacoste E, Gagnon G . Effects of calcium and thrombin on growth factor release from platelet concentrates: kinetics and regulation of endothelial cell proliferation. Biomaterials. 2004; 25(18):4489-502. DOI: 10.1016/j.biomaterials.2003.11.013. View

11.

Amable P, Carias R, Teixeira M, da Cruz Pacheco I, Farias Correa do Amaral R, Granjeiro J . Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther. 2013; 4(3):67. PMC: 3706762. DOI: 10.1186/scrt218. View

12.

Smith L, Ma P . Nano-fibrous scaffolds for tissue engineering. Colloids Surf B Biointerfaces. 2004; 39(3):125-31. DOI: 10.1016/j.colsurfb.2003.12.004. View

13.

Rui Y, Lui P, Li G, Fu S, Lee Y, Chan K . Isolation and characterization of multipotent rat tendon-derived stem cells. Tissue Eng Part A. 2009; 16(5):1549-58. DOI: 10.1089/ten.TEA.2009.0529. View

14.

Yang F, Liao C, Wu C, Shih Y, Wu L, Chen H . Effects of applying platelet-rich plasma during arthroscopic rotator cuff repair: a systematic review and meta-analysis of randomised controlled trials. Sci Rep. 2020; 10(1):17171. PMC: 7560855. DOI: 10.1038/s41598-020-74341-0. View

15.

Wu F, Nerlich M, Docheva D . Tendon injuries: Basic science and new repair proposals. EFORT Open Rev. 2017; 2(7):332-342. PMC: 5549180. DOI: 10.1302/2058-5241.2.160075. View

16.

Smith B, Grande D . The current state of scaffolds for musculoskeletal regenerative applications. Nat Rev Rheumatol. 2015; 11(4):213-22. DOI: 10.1038/nrrheum.2015.27. View

17.

Dohan Ehrenfest D, Andia I, Zumstein M, Zhang C, Pinto N, Bielecki T . Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014; 4(1):3-9. PMC: 4049647. View

18.

Okuda K, Kawase T, Momose M, Murata M, Saito Y, Suzuki H . Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro. J Periodontol. 2003; 74(6):849-57. DOI: 10.1902/jop.2003.74.6.849. View

19.

Benjamin M, Ralphs J . The cell and developmental biology of tendons and ligaments. Int Rev Cytol. 2000; 196:85-130. DOI: 10.1016/s0074-7696(00)96003-0. View

20.

James R, Kesturu G, Balian G, Chhabra A . Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options. J Hand Surg Am. 2008; 33(1):102-12. DOI: 10.1016/j.jhsa.2007.09.007. View