Can Previous Associations of Single Nucleotide Polymorphisms in the , , , and Genes in the Susceptibility to and Severity of Infections Be Confirmed?

Overview

Journal Pathogens

Date 2021 Jan 12

PMID 33430411

Citations 2

Authors

Jelmer B Jukema

Bernice M Hoenderboom

Birgit H B van Benthem

Marianne A B van der Sande

Henry J C de Vries

Christian J P A Hoebe

Nicole H T M Dukers-Muijrers

Caroline J Bax

Servaas A Morre

Sander Ouburg

Affiliations

Soon will be listed here.

Abstract

Clear inter-individual differences exist in the response to (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPs might be used as a genetic component in a tubal-pathology predicting algorithm. Our aim was to confirm the role of four genes by investigating proven associated SNPs in the susceptibility and severity of a CT infection. A total of 1201 women from five cohorts were genotyped and analyzed for + 2477 G > A, + 32656 T -> GG, + 10950 T > C, and - 1082 A > G. Results confirmed that + 32656 T ->GG was associated with an increased risk of a symptomatic CT infection (OR: 1.9, 95%CI: 1.1-3.4, = 0.02), but we did not observe an association with late complications. - 1082 A > G appeared to increase the risk of late complications (i.e., ectopic pregnancy/tubal factor infertility) following a CT infection (OR = 2.8, 95%CI: 1.1-7.1, = 0.02). Other associations were not found. Confirmatory studies are important, and large cohorts are warranted to further investigate SNPs' role in the susceptibility and severity of a CT infection.

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