Advances in Biomaterials and Regenerative Medicine for Primary Ovarian Insufficiency Therapy

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2021 Jan 11

PMID 33426370

Citations 24

Authors

Sichen Zhang

Dashuai Zhu

Xuan Mei

Zhenhua Li

Junlang Li

Mengjie Xie

Halle Jiang Williams Xie

Shaowei Wang

Ke Cheng

Affiliations

Soon will be listed here.

Abstract

Primary ovarian insufficiency (POI) is an ovarian dysfunction that affects more than 1 % of women and is characterized by hormone imbalances that afflict women before the age of 40. The typical perimenopausal symptoms result from abnormal levels of sex hormones, especially estrogen. The most prevalent treatment is hormone replacement therapy (HRT), which can relieve symptoms and improve quality of life. However, HRT cannot restore ovarian functions, including secretion, ovulation, and fertility. Recently, as part of a developing field of regenerative medicine, stem cell therapy has been proposed for the treatment of POI. Thus, we recapitulate the literature focusing on the use of stem cells and biomaterials for POI treatment, and sum up the underlying mechanisms of action. A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies.

Citing Articles

Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency.

Zhang X, Ma L, Liu X, Zhou X, Wang A, Lai Y Mater Today Bio. 2025; 31:101469.

PMID: 39906205 PMC: 11790500. DOI: 10.1016/j.mtbio.2025.101469.

Exploring the innovative application of cerium oxide nanoparticles for addressing oxidative stress in ovarian tissue regeneration.

Lakshmanan M, Saini M, Nune M J Ovarian Res. 2024; 17(1):241.

PMID: 39633503 PMC: 11619646. DOI: 10.1186/s13048-024-01566-2.

Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway.

He J, Ao C, Li M, Deng T, Zheng S, Zhang K Stem Cell Res Ther. 2024; 15(1):300.

PMID: 39272156 PMC: 11401318. DOI: 10.1186/s13287-024-03926-7.

Human Amniotic Epithelial Stem Cells Alleviate Autoimmune Premature Ovarian Insufficiency in Mice by Targeting Granulosa Cells via AKT/ERK Pathways.

Ye X, Lin Y, Ying Y, Shen X, Ni F, Wang F Stem Cell Rev Rep. 2024; 20(6):1618-1635.

PMID: 38831179 PMC: 11319531. DOI: 10.1007/s12015-024-10745-z.

hUCMSC-derived extracellular vesicles relieve cisplatin-induced granulosa cell apoptosis in mice by transferring anti-apoptotic miRNAs.

Tang W, Yan H, Chen X, Pu Y, Qi X, Dong L J Biomed Res. 2024; 39(1):36-49.

PMID: 38808551 PMC: 11873591. DOI: 10.7555/JBR.37.20230310.

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