Bone Marrow Mesenchymal Stem Cells in Premature Ovarian Failure: Mechanisms and Prospects

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Nov 17

PMID 36389844

Authors

Yanjing Huang

Mengdi Zhu

Zhuo Liu

Runan Hu

Fan Li

Yufan Song

Yuli Geng

Wenwen Ma

Kunkun Song

Mingmin Zhang

Affiliations

Soon will be listed here.

Abstract

Premature ovarian failure (POF) is a common female reproductive disorder and characterized by menopause, increased gonadotropin levels and estrogen deficiency before the age of 40 years old. The etiologies and pathogenesis of POF are not fully clear. At present, hormone replacement therapy (HRT) is the main treatment options for POF. It helps to ameliorate perimenopausal symptoms and related health risks, but can't restore ovarian function and fertility fundamentally. With the development of regenerative medicine, bone marrow mesenchymal stem cells (BMSCs) have shown great potential for the recovery of ovarian function and fertility based on the advantages of abundant sources, high capacity for self-renewal and differentiation, low immunogenicity and less ethical considerations. This systematic review aims to summarize the possible therapeutic mechanisms of BMSCs for POF. A detailed search strategy of preclinical studies and clinical trials on BMSCs and POF was performed on PubMed, MEDLINE, Web of Science and Embase database. A total of 21 studies were included in this review. Although the standardization of BMSCs need more explorations, there is no doubt that BMSCs transplantation may represent a prospective therapy for POF. It is hope to provide a theoretical basis for further research and treatment for POF.

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