The Expression of Myeloperoxidase in Thrombi is Associated with Reduced Heme Oxygenase-1 Induction and Worse Left Ventricular Remodeling in Patients with Acute ST-elevation Myocardial Infarction

Overview

Journal Clin Cardiol

Specialty Cardiology & Vascular Diseases

Date 2021 Jan 7

PMID 33410147

Citations 3

Authors

Xibao Shi

Tianqi Zhu

Jun Ni

Ruiyan Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Myeloperoxidase (MPO) secreted by neutrophils is the enzyme that kills bacteria and other pathogens. Acute myocardial infarction (AMI) is usually caused by thrombosis in response to vulnerable plaque rupture. Circulating MPO was found to be associated with increased mortality in AMI patients. However, the relationship between MPO in thrombi and the prognosis of AMI patients remains unknown.

Hypothesis: MPO expression in thrombi is associated with the prognosis of patients who underwent primary percutaneous coronary intervention (PCI) after AMI.

Methods: We observed that increased MPO was associated with lower left ventricular ejection fraction (LVEF) and worse LV remodeling in AMI patients. Instead, patients with decreased thrombotic MPO induction had a considerable improvement in LVEF 1 month after discharge (54.4 ± 2.0% vs. 61.1 ± 2.3%, p < 0.01). In the MPO group, a reduction in the thrombotic HO-1 level contributed to the development of adverse LV remodeling. Logistic regression showed that MPO was a considerable risk factor for adverse LV remodeling (adjusted OR 3.70, p < 0.05).

Conclusion: MPO expression in thrombi is associated with reduced LVEF and deteriorated LV remodeling in AMI patients, which may be due to HO-1 suppression in thrombi.

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