Effects of Time-restricted Feeding in Weight Loss, Metabolic Syndrome and Cardiovascular Risk in Obese Women

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2021 Jan 7

PMID 33407612

Citations 53

Authors

Jessica D Schroder

Hugo Falqueto

Aline Manica

Daniela Zanini

Tacio de Oliveira

Clodoaldo A de Sa

Andreia Machado Cardoso

Leandro Henrique Manfredi

Affiliations

Soon will be listed here.

Abstract

Background: The increasing prevalence of overweight and obesity among the worldwide population has been associated with a range of adverse health consequences such as Type 2 diabetes and cardiovascular diseases. The metabolic syndrome (MetS) is a cluster of cardiometabolic abnormalities that occur more commonly in overweight individuals. Time-restricted feeding (TRF) is a dietary approach used for weight loss and overall health. TRF may be an option for those subjects who struggle with extreme restriction diets with foods that generally do not belong to an individual's habits.

Objective: The purpose of this study was to determine the effect of TRF on body composition and the association of weight loss with metabolic and cardiovascular risks in obese middle-aged women.

Methods: A non-randomized controlled clinical trial was performed over 3 months in obese women (TRF group, n = 20, BMI 32.53 ± 1.13 vs. Control n = 12, BMI 34.55 ± 1.20). The TRF protocol adopted was 16 h without any energy intake followed by 8 h of normal food intake.

Main Outcomes And Measures: Anthropometric measurements, body composition, blood biomarkers, cardiovascular risk in 30 years (CVDRisk30y), and quality of life were evaluated at baseline and after the 3 months.

Results: TRF was effective in reducing weight (~ 4 kg), BMI, % of body fat (%BF), waist circumference from baseline without changes in blood biomarkers associated with MetS. TRF promoted a reduction in CVDRisk30y (12%) wich was moderately correlated with %BF (r = 0.62, n = 64, p < 0.001) and %MM (r = - 0.74, n = 64, p < 0.001).

Conclusions: TRF protocol reduces body weight without changes in biomarkers related to MetS. In addition, the anthropometric evaluation that predicts %BF and %MM could be used as an approach to follow individuals engaged in the TRF regimen since they correlate with cardiovascular risk.

Citing Articles

Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?.

Parrotta M, Colangeli L, Scipione V, Vitale C, Sbraccia P, Guglielmi V Curr Obes Rep. 2025; 14(1):17.

PMID: 39899119 PMC: 11790783. DOI: 10.1007/s13679-025-00609-z.

Evaluating the effects of time-restricted eating on overweight and obese women with polycystic ovary syndrome: A randomized controlled trial study protocol.

Liu H, Shangguan F, Liu F, Guo Y, Yu H, Li H PLoS One. 2025; 20(1):e0316333.

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Weight-neutral early time-restricted eating improves glycemic variation and time in range without changes in inflammatory markers.

Bruno J, Walker J, Nasserifar S, Upadhyay D, Ronning A, Vanegas S iScience. 2025; 27(12):111501.

PMID: 39759025 PMC: 11699278. DOI: 10.1016/j.isci.2024.111501.

New insight on the potential detrimental effect of metabolic syndrome on the Alzheimer disease neuropathology: Mechanistic role.

Ali N, Al-Kuraishy H, Al-Gareeb A, Alexiou A, Papadakis M, Bahaa M J Cell Mol Med. 2024; 28(23):e70118.

PMID: 39644152 PMC: 11624485. DOI: 10.1111/jcmm.70118.

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