Protective Role of Nrf2 in Renal Disease

Overview

Journal Antioxidants (Basel)

Date 2021 Jan 5

PMID 33396350

Citations 42

Authors

Melania Guerrero-Hue

Sandra Rayego-Mateos

Cristina Vazquez-Carballo

Alejandra Palomino-Antolin

Cristina Garcia-Caballero

Lucas Opazo-Rios

Jose Luis Morgado-Pascual

Carmen Herencia

Sebastian Mas

Alberto Ortiz

Alfonso Rubio-Navarro

Javier Egea

Jose Manuel Villalba

Jesus Egido

Juan Antonio Moreno

Affiliations

Soon will be listed here.

Abstract

Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or prevent CKD progression remain an unmet need. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that plays a key role in protection against oxidative stress and regulation of the inflammatory response. Consequently, the use of compounds targeting Nrf2 has generated growing interest for nephrologists. Pre-clinical and clinical studies have demonstrated that Nrf2-inducing strategies prevent CKD progression and protect from acute kidney injury (AKI). In this article, we review current knowledge on the protective mechanisms mediated by Nrf2 against kidney injury, novel therapeutic strategies to induce Nrf2 activation, and the status of ongoing clinical trials targeting Nrf2 in renal diseases.

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