Air Pollution and Central Nervous System Disease: A Review of the Impact of Fine Particulate Matter on Neurological Disorders

Overview

Journal Front Public Health

Specialty Public Health

Date 2021 Jan 4

PMID 33392129

Citations 36

Authors

Hyunyoung Kim

Won-Ho Kim

Young-Youl Kim

Hyun-Young Park

Affiliations

Soon will be listed here.

Abstract

It is widely known that the harmful effects of fine dust can cause various diseases. Research on the correlation between fine dust and health has been mainly focused on lung and cardiovascular diseases. By contrast, the effects of air pollution on the central nervous system (CNS) are not broadly recognized. Air pollution can cause diverse neurological disorders as the result of inflammation of the nervous system, oxidative stress, activation of microglial cells, protein condensation, and cerebral vascular-barrier disorders, but uncertainty remains concerning the biological mechanisms by which air pollution produces neurological disease. Neuronal cell damage caused by fine dust, especially in fetuses and infants, can cause permanent brain damage or lead to neurological disease in adulthood. It is necessary to study the air pollution-CNS disease connection with particular care and commitment. Moreover, the epidemiological and experimental study of the association between exposure to air pollution and CNS damage is critical to public health and quality of life. Here, we summarize the correlations between fine dust exposure and neurological disorders reported so far and make suggestions on the direction future research should take.

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References

Luyten L, Saenen N, Janssen B, Vrijens K, Plusquin M, Roels H . Air pollution and the fetal origin of disease: A systematic review of the molecular signatures of air pollution exposure in human placenta. Environ Res. 2018; 166:310-323. DOI: 10.1016/j.envres.2018.03.025. View

Calderon-Garciduenas L, Solt A, Henriquez-Roldan C, Torres-Jardon R, Nuse B, Herritt L . Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children.... Toxicol Pathol. 2008; 36(2):289-310. DOI: 10.1177/0192623307313011. View

Zeng Y, Lin R, Liu L, Liu Y, Li Y . Ambient air pollution exposure and risk of depression: A systematic review and meta-analysis of observational studies. Psychiatry Res. 2019; 276:69-78. DOI: 10.1016/j.psychres.2019.04.019. View

Nabizadeh R, Yousefian F, Kazemi Moghadam V, Hadei M . Characteristics of cohort studies of long-term exposure to PM: a systematic review. Environ Sci Pollut Res Int. 2019; 26(30):30755-30771. DOI: 10.1007/s11356-019-06382-6. View

Chen L, Yokel R, Hennig B, Toborek M . Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature. J Neuroimmune Pharmacol. 2008; 3(4):286-95. PMC: 2771674. DOI: 10.1007/s11481-008-9131-5. View

Tong H . Dietary and pharmacological intervention to mitigate the cardiopulmonary effects of air pollution toxicity. Biochim Biophys Acta. 2016; 1860(12):2891-8. DOI: 10.1016/j.bbagen.2016.05.014. View

Bai L, Zhang X, Zhang Y, Cheng Q, Duan J, Gao J . Ambient concentrations of NO and hospital admissions for schizophrenia. Occup Environ Med. 2018; 76(2):125-131. DOI: 10.1136/oemed-2018-105162. View

Szyszkowicz M, Kousha T, Kingsbury M, Colman I . Air Pollution and Emergency Department Visits for Depression: A Multicity Case-Crossover Study. Environ Health Insights. 2016; 10:155-61. PMC: 5006648. DOI: 10.4137/EHI.S40493. View

Wang Z, Peng J, Liu P, Duan Y, Huang S, Wen Y . Association between short-term exposure to air pollution and ischemic stroke onset: a time-stratified case-crossover analysis using a distributed lag nonlinear model in Shenzhen, China. Environ Health. 2020; 19(1):1. PMC: 6941275. DOI: 10.1186/s12940-019-0557-4. View

10.

Luchi M, MUNFORD R . Binding, internalization, and deacylation of bacterial lipopolysaccharide by human neutrophils. J Immunol. 1993; 151(2):959-69. View

11.

Wei H, Liang F, Meng G, Nie Z, Zhou R, Cheng W . Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells. Sci Rep. 2016; 6:33402. PMC: 5022064. DOI: 10.1038/srep33402. View

12.

Cleary E, Cifuentes M, Grinstein G, Brugge D, Shea T . Association of Low-Level Ozone with Cognitive Decline in Older Adults. J Alzheimers Dis. 2017; 61(1):67-78. PMC: 5755393. DOI: 10.3233/JAD-170658. View

13.

Mortamais M, Pujol J, Martinez-Vilavella G, Fenoll R, Reynes C, Sabatier R . Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children. Environ Res. 2019; 178:108734. PMC: 6892268. DOI: 10.1016/j.envres.2019.108734. View

14.

Ha S, Yeung E, Bell E, Insaf T, Ghassabian A, Bell G . Prenatal and early life exposures to ambient air pollution and development. Environ Res. 2019; 174:170-175. PMC: 6541527. DOI: 10.1016/j.envres.2019.03.064. View

15.

Kloog I, Coull B, Zanobetti A, Koutrakis P, Schwartz J . Acute and chronic effects of particles on hospital admissions in New-England. PLoS One. 2012; 7(4):e34664. PMC: 3328473. DOI: 10.1371/journal.pone.0034664. View

16.

Milo R, Kahana E . Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun Rev. 2009; 9(5):A387-94. DOI: 10.1016/j.autrev.2009.11.010. View

17.

Genc S, Zadeoglulari Z, Fuss S, Genc K . The adverse effects of air pollution on the nervous system. J Toxicol. 2012; 2012:782462. PMC: 3317189. DOI: 10.1155/2012/782462. View

18.

Hartz A, Bauer B, Block M, Hong J, Miller D . Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J. 2008; 22(8):2723-33. PMC: 2493447. DOI: 10.1096/fj.08-106997. View

19.

Suades R, Padro T, Badimon L . The Role of Blood-Borne Microparticles in Inflammation and Hemostasis. Semin Thromb Hemost. 2015; 41(6):590-606. DOI: 10.1055/s-0035-1556591. View

20.

Chang K, Chang M, Muo C, Wu T, Chen C, Kao C . Increased risk of dementia in patients exposed to nitrogen dioxide and carbon monoxide: a population-based retrospective cohort study. PLoS One. 2014; 9(8):e103078. PMC: 4130523. DOI: 10.1371/journal.pone.0103078. View