Tualang Honey Improves Memory and Prevents Hippocampal Changes in Prenatally Stressed Rats

Overview

Journal Turk J Pharm Sci

Specialty Pharmacology

Date 2021 Jan 4

PMID 33389951

Citations 2

Authors

Che Badariah Abd Aziz

Hidani Hasim

Rahimah Zakaria

Asma Hayati Ahmad

Affiliations

Soon will be listed here.

Abstract

Objectives: This study investigated whether the alterations in memory and hippocampus morphology and levels of malondialdehyde (MDA) and N-methyl-D-aspartate (NMDA) receptor in the hippocampus of adult rats after prenatal stress could be prevented by administration of Tualang honey (TH).

Materials And Methods: Twenty-four pregnant rats were randomly grouped into a control group (C), a stress group (S), and a stress group treated with TH. Eight male pups from each group were randomly chosen and they were sacrificed at eight or ten weeks of age following the novel object recognition test. Their brains were removed and histological changes and levels of MDA and NMDA receptors in the hippocampus were determined.

Results: The offspring from TH group showed significantly increased preference index (p<0.05) with higher neuronal number compared to S group. A significantly lower level of MDA and NMDA receptors were shown in TH group (P<0.01; P<0.05 respectively) compared to S group. The parameters investigated were not significantly different between C and TH groups.

Conclusion: The study has shown that memory alteration, changes in hippocampus histology, MDA and NMDA receptor levels could be prevented by TH administration during prenatal stress. The results suggest the beneficial effects of Tualang honey in prenatally stressed rat offspring.

Citing Articles

Medicinal activities of Tualang honey: a systematic review.

Azman A, Tan J, Abdullah M, Bahari H, Lim V, Yong Y BMC Complement Med Ther. 2024; 24(1):358.

PMID: 39367403 PMC: 11453070. DOI: 10.1186/s12906-024-04664-2.

Honey on brain health: A promising brain booster.

Zamri N, Ghani N, Ismail C, Zakaria R, Shafin N Front Aging Neurosci. 2023; 14:1092596.

PMID: 36733498 PMC: 9887050. DOI: 10.3389/fnagi.2022.1092596.

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