Developmental Pathology, Dopamine, Stress and Schizophrenia

Overview

Journal Int J Dev Neurosci

Specialty Neurology

Date 2010 Aug 24

PMID 20727962

Citations 40

Authors

Daniel J Lodge

Anthony A Grace

Affiliations

Soon will be listed here.

Abstract

Psychological stress is a contributing factor for a wide variety of neuropsychiatric diseases including substance use disorders, anxiety, depression and schizophrenia. However, it has not been conclusively determined how stress augments the symptoms of these diseases. Here we review evidence that the ventral hippocampus may be a site of convergence whereby a number of seemingly discrete risk factors, including stress, may interact to precipitate psychosis in schizophrenia. Specifically, aberrant hippocampal activity has been demonstrated to underlie both the elevated dopamine neuron activity and associated behavioral hyperactivity to dopamine agonists in a verified animal model of schizophrenia. In addition, stress, psychostimulant drug use, prenatal infection and select genetic polymorphisms all appear to augment ventral hippocampal function that may therefore exaggerate or precipitate psychotic symptoms. Such information is critical for our understanding into the pathology of psychiatric disease with the ultimate aim being the development of more effective therapeutics.

Citing Articles

Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.

Faget L, Oriol L, Lee W, Zell V, Sargent C, Flores A Nat Commun. 2024; 15(1):4233.

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The maternal-fetal neurodevelopmental groundings of preterm birth risk.

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Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.

Faget L, Oriol L, Lee W, Sargent C, Ramanathan D, Hnasko T bioRxiv. 2023; .

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Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia.

Li J, Zhang X, Yang H, Yang M, Sun H Schizophrenia (Heidelb). 2023; 9(1):24.

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Relating parental stress with sleep disorders in parents and children.

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