Therapeutic Advances of MiRNAs: A Preclinical and Clinical Update

Overview

Journal J Adv Res

Specialties General Medicine
Science

Date 2020 Dec 28

PMID 33364050

Citations 175

Authors

Chiranjib Chakraborty

Ashish Ranjan Sharma

Garima Sharma

Sang-Soo Lee

Affiliations

Soon will be listed here.

Abstract

miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.

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