The Therapeutic Efficacy of Gel Ointment on Staphylococcal Pyoderma in Dogs

Background And Aim: Staphylococcus pyoderma is a common problem in dogs that need a novel treatment rather than antibiotic therapy. The aim of this study was to investigate the therapeutic efficacy, anti-inflammatory, and antioxidative properties of () gel ointment on dogs' Staphylococcus pyoderma compared to gentamicin ointment.

Materials And Methods: The inhibition zone of extract 20% and 40% and gentamicin 1% against was determined on well diffusion agar. Twenty Baladi local breed dogs were used as control negative group before intradermal inoculation with 10 CFU . The animals were classified into four equal groups, control positive group without treatment (n=5), treated groups by 20% gel ointment (n=5), 40% gel ointment (n=5), and gentamicin ointment 1% (n=5). Topical application of and gentamicin ointments was carried out twice daily for 2 weeks until complete healing of dogs' pyoderma. Clinical evaluation was recorded. Inflammatory, oxidant, and antioxidant parameters were measured in serum.

Results: The inhibition zone of extracts 20% and 40% was 19 mm and 23 mm, respectively, while gentamicin 1% was 18 mm. The half maximal inhibitory concentration (of 20% and 40% were 13.70 with R=0.98. Dogs' pyoderma treated with gel ointment 20% and 40% were more likely to have low haptoglobin and tumor necrosis factor-α concentrations than gentamicin 1% ([odds ratio [OR]=4.6; 95% confidence interval [CI]=1.31-17.40; p<0.05]; [OR=5.2; 95% CI=1.04-22.30; p<0.05]), respectively.

Conclusion: It seems evident that has therapeutic effect, antibacterial, and anti-inflammatory effects against dogs' staphylococcal pyoderma than gentamicin that would support its further use rather than antibiotics in one health arena.