Acute Phase Response in Animals: a Review

Overview

Journal Comp Med

Specialty General Medicine

Date 2009 Dec 26

PMID 20034426

Citations 290

Authors

Carolyn Cray

Julia Zaias

Norman H Altman

Affiliations

Soon will be listed here.

Abstract

The acute phase response is a complex systemic early-defense system activated by trauma, infection, stress, neoplasia, and inflammation. Although nonspecific, it serves as a core of the innate immune response involving physical and molecular barriers and responses that serve to prevent infection, clear potential pathogens, initiate inflammatory processes, and contribute to resolution and the healing process. Acute phase proteins, an integral part of the acute phase response, have been a focus of many applications in human diagnostic medicine and recently have been identified in common animal species. Potential applications to diagnosis, prognosis, assessment of animal health, and laboratory animal welfare are readily apparent.

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