Immunometabolism at the Cornerstone of Inflammaging, Immunosenescence, and Autoimmunity in COVID-19

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2020 Dec 28

PMID 33361522

Citations 22

Authors

Loukman Omarjee

Frederique Perrot

Olivier Meilhac

Guillaume Mahe

Guilhem Bousquet

Anne Janin

Affiliations

Soon will be listed here.

Abstract

Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.

Citing Articles

The impact of COVID-19 on accelerating of immunosenescence and brain aging.

Muller L, Di Benedetto S Front Cell Neurosci. 2024; 18:1471192.

PMID: 39720706 PMC: 11666534. DOI: 10.3389/fncel.2024.1471192.

Advanced Glycation End-Products Acting as Immunomodulators for Chronic Inflammation, Inflammaging and Carcinogenesis in Patients with Diabetes and Immune-Related Diseases.

Shen C, Lu C, Cheng C, Li K, Kuo Y, Wu C Biomedicines. 2024; 12(8).

PMID: 39200164 PMC: 11352041. DOI: 10.3390/biomedicines12081699.

Metformin Restrains the Proliferation of CD4+ T Lymphocytes by Inducing Cell Cycle Arrest in Normo- and Hyperglycemic Conditions.

Cartes-Velasquez R, Vera A, Antilef B, Sanhueza S, Lamperti L, Gonzalez-Ortiz M Biomolecules. 2024; 14(7).

PMID: 39062560 PMC: 11274706. DOI: 10.3390/biom14070846.

Non-fatal outcomes of COVID-19 disease in pediatric organ transplantation associates with down-regulation of senescence pathways.

Subramanian K, Varghese R, Pochedly M, Muralidaran V, Yazigi N, Kaufman S Sci Rep. 2024; 14(1):1877.

PMID: 38253675 PMC: 10803774. DOI: 10.1038/s41598-024-52456-y.

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology.

Roth-Walter F, Adcock I, Benito-Villalvilla C, Bianchini R, Bjermer L, Caramori G Allergy. 2023; 79(5):1089-1122.

PMID: 38108546 PMC: 11497319. DOI: 10.1111/all.15977.

References

Ruscitti P, Berardicurti O, Iagnocco A, Giacomelli R . Cytokine storm syndrome in severe COVID-19. Autoimmun Rev. 2020; 19(7):102562. PMC: 7252135. DOI: 10.1016/j.autrev.2020.102562. View

Vabret N, Britton G, Gruber C, Hegde S, Kim J, Kuksin M . Immunology of COVID-19: Current State of the Science. Immunity. 2020; 52(6):910-941. PMC: 7200337. DOI: 10.1016/j.immuni.2020.05.002. View

Hayflick L . THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res. 1965; 37:614-36. DOI: 10.1016/0014-4827(65)90211-9. View

Menendez J . Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19. Aging (Albany NY). 2020; 12(10):8760-8765. PMC: 7288975. DOI: 10.18632/aging.103347. View

Singh M, Jensen M, Lerman A, Kushwaha S, Rihal C, Gersh B . Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study. J Frailty Aging. 2016; 5(4):204-207. DOI: 10.14283/jfa.2016.112. View

Zheng M, Gao Y, Wang G, Song G, Liu S, Sun D . Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020; 17(5):533-535. PMC: 7091858. DOI: 10.1038/s41423-020-0402-2. View

Chang C, Curtis J, Maggi Jr L, Faubert B, Villarino A, OSullivan D . Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell. 2013; 153(6):1239-51. PMC: 3804311. DOI: 10.1016/j.cell.2013.05.016. View

Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q . Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020; 94:91-95. PMC: 7194638. DOI: 10.1016/j.ijid.2020.03.017. View

Ugarte-Gil M, Sanchez-Zuniga C, Gamboa-Cardenas R, Aliaga-Zamudio M, Zevallos F, Tineo-Pozo G . Circulating naive and memory CD4+ T cells and metabolic syndrome in patients with systemic lupus erythematosus: data from a primarily Mestizo population. Rheumatology (Oxford). 2014; 54(7):1302-7. DOI: 10.1093/rheumatology/keu434. View

10.

Wu Z, McGoogan J . Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323(13):1239-1242. DOI: 10.1001/jama.2020.2648. View

11.

Shenoy S . Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality. Inflamm Res. 2020; 69(11):1077-1085. PMC: 7410962. DOI: 10.1007/s00011-020-01389-z. View

12.

Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H . Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020; 130(5):2620-2629. PMC: 7190990. DOI: 10.1172/JCI137244. View

13.

Ebihara S, Tajima H, Ono M . Nuclear factor erythroid 2-related factor 2 is a critical target for the treatment of glucocorticoid-resistant lupus nephritis. Arthritis Res Ther. 2016; 18(1):139. PMC: 4908698. DOI: 10.1186/s13075-016-1039-5. View

14.

Brownlee W, Bourdette D, Broadley S, Killestein J, Ciccarelli O . Treating multiple sclerosis and neuromyelitis optica spectrum disorder during the COVID-19 pandemic. Neurology. 2020; 94(22):949-952. DOI: 10.1212/WNL.0000000000009507. View

15.

Lighter J, Phillips M, Hochman S, Sterling S, Johnson D, Francois F . Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission. Clin Infect Dis. 2020; 71(15):896-897. PMC: 7184372. DOI: 10.1093/cid/ciaa415. View

16.

Franceschi C, Campisi J . Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014; 69 Suppl 1:S4-9. DOI: 10.1093/gerona/glu057. View

17.

Lai Z, Borsuk R, Shadakshari A, Yu J, Dawood M, Garcia R . Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus. J Immunol. 2013; 191(5):2236-46. PMC: 3777662. DOI: 10.4049/jimmunol.1301005. View

18.

Lee G . The Balance of Th17 versus Treg Cells in Autoimmunity. Int J Mol Sci. 2018; 19(3). PMC: 5877591. DOI: 10.3390/ijms19030730. View

19.

Roncati L, Nasillo V, Lusenti B, Riva G . Signals of T2 immune response from COVID-19 patients requiring intensive care. Ann Hematol. 2020; 99(6):1419-1420. PMC: 7205481. DOI: 10.1007/s00277-020-04066-7. View

20.

Heath J, Grant M . The Immune Response Against Human Cytomegalovirus Links Cellular to Systemic Senescence. Cells. 2020; 9(3). PMC: 7140628. DOI: 10.3390/cells9030766. View