Cytokine Storm Syndrome in Severe COVID-19

Overview

Journal Autoimmun Rev

Publisher Elsevier

Specialty Allergy & Immunology

Date 2020 May 8

PMID 32376400

Citations 55

Authors

Piero Ruscitti

Onorina Berardicurti

Annamaria Iagnocco

Roberto Giacomelli

Affiliations

Soon will be listed here.

Citing Articles

Terpenes and cannabidiol against human corona and influenza viruses-Anti-inflammatory and antiviral in vitro evaluation.

Chatow L, Nudel A, Eyal N, Lupo T, Ramirez S, Zelinger E Biotechnol Rep (Amst). 2024; 41:e00829.

PMID: 38318445 PMC: 10840330. DOI: 10.1016/j.btre.2024.e00829.

Dynamic Assessment of Plasma von Willebrand Factor and ADAMTS13 Predicts Mortality in Hospitalized Patients with SARS-CoV-2 Infection.

Zhang Q, Bignotti A, Yada N, Ye Z, Liu S, Han Z J Clin Med. 2023; 12(22).

PMID: 38002786 PMC: 10672082. DOI: 10.3390/jcm12227174.

The prevalence and contributing risk factors of coronavirus disease 2019 infection in patients with metabolic syndrome.

Bagheri-Hosseinabadi Z, Moadab F, Amiri A, Abbasifard M BMC Endocr Disord. 2023; 23(1):100.

PMID: 37142990 PMC: 10157563. DOI: 10.1186/s12902-023-01351-0.

Increased Incidence of Pancreatic Steatosis Detected Using Computed Tomography at Initial Diagnosis of Coronavirus Disease 2019.

Oz A, Akcalar S Turk J Gastroenterol. 2023; 34(3):270-277.

PMID: 36919831 PMC: 10152160. DOI: 10.5152/tjg.2023.22471.

Phytocannabinoids Act Synergistically with Non-Steroidal Anti-Inflammatory Drugs Reducing Inflammation in 2D and 3D In Vitro Models.

Vinayaka A, Shalev N, Anil S, Tiwari S, Kumar N, Belausov E Pharmaceuticals (Basel). 2022; 15(12).

PMID: 36559009 PMC: 9787964. DOI: 10.3390/ph15121559.

References

Guo Y, Cao Q, Hong Z, Tan Y, Chen S, Jin H . The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020; 7(1):11. PMC: 7068984. DOI: 10.1186/s40779-020-00240-0. View

Shimabukuro-Vornhagen A, Godel P, Subklewe M, Stemmler H, Schlosser H, Schlaak M . Cytokine release syndrome. J Immunother Cancer. 2018; 6(1):56. PMC: 6003181. DOI: 10.1186/s40425-018-0343-9. View

Henter J, Horne A, Arico M, Egeler R, Filipovich A, Imashuku S . HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2006; 48(2):124-31. DOI: 10.1002/pbc.21039. View

Ramos-Casals M, Brito-Zeron P, Lopez-Guillermo A, Khamashta M, Bosch X . Adult haemophagocytic syndrome. Lancet. 2013; 383(9927):1503-1516. DOI: 10.1016/S0140-6736(13)61048-X. View

Behrens E, Canna S, Slade K, Rao S, Kreiger P, Paessler M . Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest. 2011; 121(6):2264-77. PMC: 3104738. DOI: 10.1172/JCI43157. View

Pedersen S, Ho Y . SARS-CoV-2: a storm is raging. J Clin Invest. 2020; 130(5):2202-2205. PMC: 7190904. DOI: 10.1172/JCI137647. View

Karakike E, Giamarellos-Bourboulis E . Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis. Front Immunol. 2019; 10:55. PMC: 6365431. DOI: 10.3389/fimmu.2019.00055. View

Castillo L, Carcillo J . Secondary hemophagocytic lymphohistiocytosis and severe sepsis/ systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation. Pediatr Crit Care Med. 2009; 10(3):387-92. DOI: 10.1097/PCC.0b013e3181a1ae08. View

Ruscitti P, Cipriani P, Di Benedetto P, Liakouli V, Carubbi F, Berardicurti O . Advances in immunopathogenesis of macrophage activation syndrome during rheumatic inflammatory diseases: toward new therapeutic targets?. Expert Rev Clin Immunol. 2017; 13(11):1041-1047. DOI: 10.1080/1744666X.2017.1372194. View

10.

Lykens J, Terrell C, Zoller E, Risma K, Jordan M . Perforin is a critical physiologic regulator of T-cell activation. Blood. 2011; 118(3):618-26. PMC: 3142903. DOI: 10.1182/blood-2010-12-324533. View

11.

Shoenfeld Y . Corona (COVID-19) time musings: Our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning. Autoimmun Rev. 2020; 19(6):102538. PMC: 7131471. DOI: 10.1016/j.autrev.2020.102538. View

12.

Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H . Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020; 8(5):475-481. PMC: 7102538. DOI: 10.1016/S2213-2600(20)30079-5. View

13.

Canna S, Behrens E . Making sense of the cytokine storm: a conceptual framework for understanding, diagnosing, and treating hemophagocytic syndromes. Pediatr Clin North Am. 2012; 59(2):329-44. PMC: 3368378. DOI: 10.1016/j.pcl.2012.03.002. View

14.

Wang F, Nie J, Wang H, Zhao Q, Xiong Y, Deng L . Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia. J Infect Dis. 2020; 221(11):1762-1769. PMC: 7184346. DOI: 10.1093/infdis/jiaa150. View

15.

Weaver L, Behrens E . Hyperinflammation, rather than hemophagocytosis, is the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis. Curr Opin Rheumatol. 2014; 26(5):562-9. PMC: 4227502. DOI: 10.1097/BOR.0000000000000093. View

16.

Kagi D, Odermatt B, Mak T . Homeostatic regulation of CD8+ T cells by perforin. Eur J Immunol. 1999; 29(10):3262-72. DOI: 10.1002/(SICI)1521-4141(199910)29:10<3262::AID-IMMU3262>3.0.CO;2-A. View

17.

Caso F, Costa L, Ruscitti P, Navarini L, Del Puente A, Giacomelli R . Could Sars-coronavirus-2 trigger autoimmune and/or autoinflammatory mechanisms in genetically predisposed subjects?. Autoimmun Rev. 2020; 19(5):102524. PMC: 7271072. DOI: 10.1016/j.autrev.2020.102524. View

18.

Grom A, Horne A, De Benedetti F . Macrophage activation syndrome in the era of biologic therapy. Nat Rev Rheumatol. 2016; 12(5):259-68. PMC: 5851441. DOI: 10.1038/nrrheum.2015.179. View

19.

Cifaldi L, Prencipe G, Caiello I, Bracaglia C, Locatelli F, De Benedetti F . Inhibition of natural killer cell cytotoxicity by interleukin-6: implications for the pathogenesis of macrophage activation syndrome. Arthritis Rheumatol. 2015; 67(11):3037-46. DOI: 10.1002/art.39295. View

20.

Zheng M, Gao Y, Wang G, Song G, Liu S, Sun D . Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020; 17(5):533-535. PMC: 7091858. DOI: 10.1038/s41423-020-0402-2. View