Adipokines and Arterial Stiffness in the Elderly

Overview

Journal Vasc Health Risk Manag

Publisher Dove Medical Press

Specialty Cardiology & Vascular Diseases

Date 2020 Dec 16

PMID 33324067

Citations 9

Authors

Francesco Fantin

Eleonora Disegna

Gisella Manzato

Gabriele Comellato

Elena Zoico

Andrea P Rossi

Gloria Mazzali

Chakravarthi Rajkumar

Mauro Zamboni

Affiliations

Soon will be listed here.

Abstract

Introduction: The aim of this study was to evaluate the relationship between adipokines and arterial stiffness in a group of 85 elderly subjects and the role of leptin and adiponectin on subclinical vascular damage, defined by a PWV>10 m/s.

Methods: In each subject, we evaluated anthropometry, body composition by DXA (fat mass, fat mass%, lean mass), metabolic variables, leptin, adiponectin, systolic, diastolic, mean arterial pressure and pulse pressure (SBP, DBP, MAP, PP), carotid-femoral pulse wave velocity (cfPWV) and carotid-radial pulse wave velocity (crPWV).

Results: In the study population, significant associations were observed between cfPWV and crPWV, age, SBP, MAP, waist circumference, fat body mass and leptin. The study population was subdivided in 2 subgroups according to adipokine patterns: group 1 included patients with high adiponectin and low leptin, and group 2 patients had high leptin and low adiponectin. SBP, PP, cfPWV were significantly higher in subjects with high leptin and low adiponectin (group 2). Even after adjustment for gender, fat mass%, MAP, HDL cholesterol and triglycerides, cfPWV was higher in group 2 than group 1. In a logistic binary regression on the entire population, considering subclinical vascular damage as a dependent variable and age, gender, MAP, fat mass%, triglycerides, HDL cholesterol and category of subjects with high leptin and low adiponectin as independent variables, MAP and category of subjects with high leptin and low adiponectin were significant predictors (OR, respectively, 1.09 and 3.61).

Conclusion: In conclusion, in the elderly, the presence at the same time of high leptin levels and low adiponectin levels seems to have synergic effects on arterial stiffness.

Citing Articles

Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults.

Fantin F, Giani A, Manzato G, Zampieri A, Comellato G, Urbani S Front Cardiovasc Med. 2024; 11:1272854.

PMID: 38404726 PMC: 10885346. DOI: 10.3389/fcvm.2024.1272854.

Predictive value of estimated pulse wave velocity for cardiovascular and all-cause mortality in individuals with obesity.

Li D, Cao F, Cheng W, Xu Y, Yang C Diabetol Metab Syndr. 2023; 15(1):40.

PMID: 36894988 PMC: 9997019. DOI: 10.1186/s13098-023-01011-2.

Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise.

Minniti G, Pescinini-Salzedas L, Minniti G, Fornari Laurindo L, Barbalho S, Sinatora R Int J Mol Sci. 2022; 23(21).

PMID: 36362238 PMC: 9655425. DOI: 10.3390/ijms232113452.

The Correlation of Arterial Stiffness Parameters with Aging and Comorbidity Burden.

Fantin F, Giani A, Trentin M, Rossi A, Zoico E, Mazzali G J Clin Med. 2022; 11(19).

PMID: 36233629 PMC: 9572768. DOI: 10.3390/jcm11195761.

Waist Circumference: A Parameter of Vascular Health.

Campana E, Brandao A Arq Bras Cardiol. 2022; 119(2):265-266.

PMID: 35946688 PMC: 9363067. DOI: 10.36660/abc.20220508.

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