The Correlation of Arterial Stiffness Parameters with Aging and Comorbidity Burden

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 Oct 14

PMID 36233629

Authors

Francesco Fantin

Anna Giani

Monica Trentin

Andrea P Rossi

Elena Zoico

Gloria Mazzali

Rocco Micciolo

Mauro Zamboni

Affiliations

Soon will be listed here.

Abstract

The aim of the study was to evaluate the relationships between carotid-femoral pulse wave velocity (PVW-cf), cardio-ankle vascular index (CAVI) and CAVI0 (which is a mathematical elaboration of CAVI, theoretically less dependent on blood pressure), age and comorbidity burden. Furthermore, 183 patients (119 female, mean age 67.5 ± 14.3 years) referred to the Geriatric Ward and Outpatient Clinic at Verona University Hospital were included; demographic, clinical and blood analysis data were collected. Charlson Comorbidity Index (CCI), PVW-cf, CAVI and CAVI 0 were obtained. Significant correlations were found between CAVI, CAVI0, PVW-cf and both age (r = 0.698, r = 0.717, r = 0.410, respectively p < 0.001 for all) and CCI, (r = 0.654; r = 0.658; r = 0.448 respectively and p < 0.001 for all), still significant after adjustment for several variables. In a stepwise multiple regression model, considering several variables, CCI was the only predictor of PWV-cf, whereas age and CCI were significant predictors of both CAVI and CAVI 0. In conclusion, all arterial stiffness indexes are associated with CCI and aging; the latter correlation is more evident for CAVI and CAVI 0 than for PVW-cf. Arterial stiffness parameters can complement the characterization of patients affected by a remarkable comorbidity burden across aging; arterial stiffening might mirror the complexity of these individuals.

Citing Articles

Cardio-Ankle Vascular Index and Aging: Differences between CAVI and CAVI0.

Giani A, Micciolo R, Zoico E, Mazzali G, Zamboni M, Fantin F J Clin Med. 2023; 12(21).

PMID: 37959192 PMC: 10647579. DOI: 10.3390/jcm12216726.

References

Kirigaya J, Iwahashi N, Tahakashi H, Minamimoto Y, Gohbara M, Abe T . Impact of Cardio-Ankle Vascular Index on Long-Term Outcome in Patients with Acute Coronary Syndrome. J Atheroscler Thromb. 2019; 27(7):657-668. PMC: 7406412. DOI: 10.5551/jat.51409. View

Suzuki J, Sakakibara R, Tomaru T, Tateno F, Kishi M, Ogawa E . Stroke and cardio-ankle vascular stiffness index. J Stroke Cerebrovasc Dis. 2011; 22(2):171-5. DOI: 10.1016/j.jstrokecerebrovasdis.2011.07.010. View

Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac A . Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension. 1995; 26(3):485-90. DOI: 10.1161/01.hyp.26.3.485. View

Izuhara M, Shioji K, Kadota S, Baba O, Takeuchi Y, Uegaito T . Relationship of cardio-ankle vascular index (CAVI) to carotid and coronary arteriosclerosis. Circ J. 2008; 72(11):1762-7. DOI: 10.1253/circj.cj-08-0152. View

Van Bortel L, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank J, De Backer T . Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012; 30(3):445-8. DOI: 10.1097/HJH.0b013e32834fa8b0. View

Choi S, Oh B, Park J, Choi D, Rhee M, Park S . Age-associated increase in arterial stiffness measured according to the cardio-ankle vascular index without blood pressure changes in healthy adults. J Atheroscler Thromb. 2013; 20(12):911-23. DOI: 10.5551/jat.18267. View

Ibata J, Sasaki H, Hanabusa T, Wakasaki H, Furuta H, Nishi M . Increased arterial stiffness is closely associated with hyperglycemia and improved by glycemic control in diabetic patients. J Diabetes Investig. 2014; 4(1):82-7. PMC: 4019292. DOI: 10.1111/j.2040-1124.2012.00229.x. View

Nagayama D, Watanabe Y, Saiki A, Shirai K, Tatsuno I . Difference in positive relation between cardio-ankle vascular index (CAVI) and each of four blood pressure indices in real-world Japanese population. J Hum Hypertens. 2019; 33(3):210-217. DOI: 10.1038/s41371-019-0167-1. View

Satoh N, Shimatsu A, Kato Y, Araki R, Koyama K, Okajima T . Evaluation of the cardio-ankle vascular index, a new indicator of arterial stiffness independent of blood pressure, in obesity and metabolic syndrome. Hypertens Res. 2008; 31(10):1921-30. DOI: 10.1291/hypres.31.1921. View

10.

Shirai K . Analysis of vascular function using the cardio-ankle vascular index (CAVI). Hypertens Res. 2011; 34(6):684-5. DOI: 10.1038/hr.2011.40. View

11.

Namekata T, Suzuki K, Ishizuka N, Shirai K . Establishing baseline criteria of cardio-ankle vascular index as a new indicator of arteriosclerosis: a cross-sectional study. BMC Cardiovasc Disord. 2011; 11:51. PMC: 3166915. DOI: 10.1186/1471-2261-11-51. View

12.

Nakamura K, Tomaru T, Yamamura S, Miyashita Y, Shirai K, Noike H . Cardio-ankle vascular index is a candidate predictor of coronary atherosclerosis. Circ J. 2008; 72(4):598-604. DOI: 10.1253/circj.72.598. View

13.

Saiki A, Ohira M, Yamaguchi T, Nagayama D, Shimizu N, Shirai K . New Horizons of Arterial Stiffness Developed Using Cardio-Ankle Vascular Index (CAVI). J Atheroscler Thromb. 2020; 27(8):732-748. PMC: 7458785. DOI: 10.5551/jat.RV17043. View

14.

Di Pino A, Alagona C, Piro S, Calanna S, Spadaro L, Palermo F . Separate impact of metabolic syndrome and altered glucose tolerance on early markers of vascular injuries. Atherosclerosis. 2012; 223(2):458-62. DOI: 10.1016/j.atherosclerosis.2012.05.008. View

15.

Tsuboi A, Ito C, Fujikawa R, Yamamoto H, Kihara Y . Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects. Intern Med. 2015; 54(16):1961-9. DOI: 10.2169/internalmedicine.54.3596. View

16.

Hayashi K, Yamamoto T, Takahara A, Shirai K . Clinical assessment of arterial stiffness with cardio-ankle vascular index: theory and applications. J Hypertens. 2015; 33(9):1742-57. DOI: 10.1097/HJH.0000000000000651. View

17.

Xue Q, Qin M, Jia J, Liu J, Wang Y . Association between frailty and the cardio-ankle vascular index. Clin Interv Aging. 2019; 14:735-742. PMC: 6487894. DOI: 10.2147/CIA.S195109. View

18.

Shirai K, Utino J, Otsuka K, Takata M . A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006; 13(2):101-7. DOI: 10.5551/jat.13.101. View

19.

McVeigh G, Bratteli C, Morgan D, Alinder C, Glasser S, Finkelstein S . Age-related abnormalities in arterial compliance identified by pressure pulse contour analysis: aging and arterial compliance. Hypertension. 1999; 33(6):1392-8. DOI: 10.1161/01.hyp.33.6.1392. View

20.

Shirai K, Song M, Suzuki J, Kurosu T, Oyama T, Nagayama D . Contradictory effects of β1- and α1- aderenergic receptor blockers on cardio-ankle vascular stiffness index (CAVI)--CAVI independent of blood pressure. J Atheroscler Thromb. 2010; 18(1):49-55. DOI: 10.5551/jat.3582. View