Green Synthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Activity Against Multidrug-Resistant Bacteria and Wound Healing Efficacy Using a Murine Model

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2020 Dec 16

PMID 33322213

Citations 27

Authors

Vajravathi Lakkim

Madhava C Reddy

Roja Rani Pallavali

Kakarla Raghava Reddy

Ch Venkata Reddy

Inamuddin

Anwar L Bilgrami

Dakshayani Lomada

Affiliations

Soon will be listed here.

Abstract

Green nanotechnology has significant applications in various biomedical science fields. In this study, green-synthesized silver nanoparticles, prepared by using and extracts, were characterized using UV-Vis spectroscopy, dynamic light scattering, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. Silver nanoparticles (Ag NPs) synthesized from leaf extracts of and effectively inhibited the growth of multidrug-resistant (MDR) bacteria isolated from patients with septic wound infections. The maximum bacteriolytic activity of the green-synthesized Ag NPs of and against the MDR bacterium was shown by a zone of inhibition of 19 and 16 mm, respectively. Ag NPs exhibited more bacteriolytic activity than Ag NPs in terms of the zone of inhibition. Moreover, these particles were effective in healing wounds in BALB/c mice. Ag NPs of and enhanced wound healing by 94% ± 1% and 87% ± 1%, respectively. Our data suggest that Ag NPs from and ameliorate excision wounds, and wound healing could be due to their effective antimicrobial activity against MDR bacteria. Hence, these Ag NPs could be potential therapeutic agents for the treatment of wounds.

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