Definitive Intensity-modulated Radiotherapy or Surgery for Early Oral Cavity Squamous Cell Carcinoma: Propensity-score-matched, Nationwide, Population-based Cohort Study

Overview

Journal Head Neck

Specialties General Surgery
Oncology

Date 2020 Dec 14

PMID 33314548

Citations 12

Authors

Wen-Chi Liu

Hsueh-Erh Liu

Yi-Wei Kao

Lei Qin

Kuan-Chou Lin

Chih-Yuan Fang

Lo-Lin Tsai

Ben-Chang Shia

Szu-Yuan Wu

Affiliations

Soon will be listed here.

Abstract

Background: No evidence is currently available to estimate the outcomes of intensity-modulated radiation therapy (IMRT) and surgery for patients with early oral cavity squamous cell carcinoma (E-OCSCC).

Methods: We recruited patients from the Taiwan Cancer Registry Database who had received a diagnosis of E-OCSCC. Propensity score matching was performed, and Cox proportional hazards model was used to analyze all-cause mortality.

Results: In the multivariate Cox regression analyses, the adjusted hazard ratio (aHR) (95% confidence interval [CI]) for surgery compared with definitive IMRT, T2N0M0 compared with T1N0M0, and male patients compared with female patients were 0.303 (0.245, 0.375), 1.340 (1.077, 1.668), and 2.012 (1.432, 2.826), respectively. The aHRs (95% CIs) for age 61 to 70, 71 to 80, and ≧81 years compared with <40 years were 2.984 (1.43, 4.225), 3.353 (2.578, 4.112), and 4.277 (4.104, 5.679), respectively.

Conclusions: For patients with E-OCSCC, surgery may be considered the first option rather than definitive IMRT.

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