H1-antihistamine Use and Head and Neck Cancer Risk in Type 2 Diabetes Mellitus

Overview

Journal Oncol Res

Specialty Oncology

Date 2023 Jun 12

PMID 37303737

Authors

Yi-Nong Chen

Ying-Lin Chen

Wan-Ming Chen

Mingchih Chen

Ben-Chang Shia

Jenq-Yuh Ko

Szu-Yuan Wu

Affiliations

Soon will be listed here.

Abstract

This study aimed to examine the association between the use of H1-antihistamines (AHs) and head and neck cancer (HNC) risk in patients with type 2 diabetes mellitus (T2DM). Data from the National Health Insurance Research Database of Taiwan were analyzed for the period from 2008 to 2018. A propensity-score-matched cohort of 54,384 patients each in the AH user and nonuser groups was created and analyzed using Kaplan-Meier method and Cox proportional hazards regression. The results showed that the risk of HNC was significantly lower in AH users (adjusted hazard ratio: 0.55, 95% CI: 0.48 to 0.64) and the incidence rate was also lower (5.16 . 8.10 per 100,000 person-years). The lower HNC incidence rate in AH users (95% CI: 0.63; 0.55 to 0.73) suggests that AH use may reduce the risk of HNC in T2DM patients.

Citing Articles

E2F1 Promotes the Occurrence of Head and Neck Squamous Cell Carcinoma and Serves as a Prognostic Biomarker.

Wang J, Cui Z, Hei N, Yang Q, Peng S Appl Biochem Biotechnol. 2024; 197(2):1258-1279.

PMID: 39565537 DOI: 10.1007/s12010-024-05097-w.

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