Light Pollution and Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Dec 11

PMID 33302582

Citations 29

Authors

William H Walker 2nd

Jacob R Bumgarner

James C Walton

Jennifer A Liu

O Hecmarie Melendez-Fernandez

Randy J Nelson

A Courtney DeVries

Affiliations

Soon will be listed here.

Abstract

For many individuals in industrialized nations, the widespread adoption of electric lighting has dramatically affected the circadian organization of physiology and behavior. Although initially assumed to be innocuous, exposure to artificial light at night (ALAN) is associated with several disorders, including increased incidence of cancer, metabolic disorders, and mood disorders. Within this review, we present a brief overview of the molecular circadian clock system and the importance of maintaining fidelity to bright days and dark nights. We describe the interrelation between core clock genes and the cell cycle, as well as the contribution of clock genes to oncogenesis. Next, we review the clinical implications of disrupted circadian rhythms on cancer, followed by a section on the foundational science literature on the effects of light at night and cancer. Finally, we provide some strategies for mitigation of disrupted circadian rhythms to improve health.

Citing Articles

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Oliveira A, Ferreira G, Martinez-Perez C Healthcare (Basel). 2024; 12(23).

PMID: 39685063 PMC: 11641230. DOI: 10.3390/healthcare12232441.

Effect of Constant Illumination on the Morphofunctional State and Rhythmostasis of Rat Livers at Experimental Toxic Injury.

Grabeklis S, Kozlova M, Mikhaleva L, Dygai A, Vandysheva R, Anurkina A Int J Mol Sci. 2024; 25(22).

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Circadian Rhythm Disruption in Cancer Survivors: From Oncogenesis to Quality of Life.

Kisamore C, Kisamore C, Walker 2nd W Cancer Med. 2024; 13(20):e70353.

PMID: 39463009 PMC: 11513439. DOI: 10.1002/cam4.70353.

A review for the impacts of circadian disturbance on urological cancers.

Li T, Jiang Y, Bai Y, Jiang K, Du G, Chen P Sleep Biol Rhythms. 2024; 22(2):163-180.

PMID: 38524168 PMC: 10959858. DOI: 10.1007/s41105-023-00500-1.

Time of day bias for biological sampling in studies of mammary cancer.

Walton J, Walker 2nd W, Nelson R, DeVries A Sci Rep. 2024; 14(1):848.

PMID: 38191908 PMC: 10774401. DOI: 10.1038/s41598-023-50785-y.

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