» Articles » PMID: 33287462

Vitamin C and Cardiovascular Disease: An Update

Overview
Date 2020 Dec 8
PMID 33287462
Citations 65
Authors
Affiliations
Soon will be listed here.
Abstract

The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.

Citing Articles

Recent Advances in Aptamers-Based Nanosystems for Diagnosis and Therapy of Cardiovascular Diseases: An Updated Review.

Yu H, Yu J, Yao G Int J Nanomedicine. 2025; 20:2427-2443.

PMID: 40034222 PMC: 11873322. DOI: 10.2147/IJN.S507715.


Vitamin C: A Comprehensive Review of Its Role in Health, Disease Prevention, and Therapeutic Potential.

Alberts A, Moldoveanu E, Niculescu A, Grumezescu A Molecules. 2025; 30(3).

PMID: 39942850 PMC: 11820684. DOI: 10.3390/molecules30030748.


Global burden of cardiovascular diseases attributable to diet low in vegetables from 1990 to 2021 and forecasting the future trends: a population-based study.

Mao Q, Kong Y Front Cardiovasc Med. 2025; 11:1491869.

PMID: 39882319 PMC: 11774848. DOI: 10.3389/fcvm.2024.1491869.


A Guinea Pig Model of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease.

Pedersen K, Poojari A, Colberg S, Mechernsee S, Iversen J, Barres R Nutrients. 2025; 17(2).

PMID: 39861421 PMC: 11767659. DOI: 10.3390/nu17020291.


Associations between oxidative balance scores and heart failure among americans: NHANES (2007-2018).

Xu X, Wang X, Han X BMC Cardiovasc Disord. 2025; 25(1):41.

PMID: 39849357 PMC: 11756190. DOI: 10.1186/s12872-024-04456-z.


References
1.
Hunt J, Gallagher S, Johnson L . Effect of ascorbic acid on apparent iron absorption by women with low iron stores. Am J Clin Nutr. 1994; 59(6):1381-5. DOI: 10.1093/ajcn/59.6.1381. View

2.
Liu X, Wang P, Zou Y, Luo Z, Tamer T . Co-encapsulation of Vitamin C and β-Carotene in liposomes: Storage stability, antioxidant activity, and in vitro gastrointestinal digestion. Food Res Int. 2020; 136:109587. DOI: 10.1016/j.foodres.2020.109587. View

3.
Carr A, Frei B . Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999; 69(6):1086-107. DOI: 10.1093/ajcn/69.6.1086. View

4.
Ulker E, Parker W, Raj A, Qu Z, May J . Ascorbic acid prevents VEGF-induced increases in endothelial barrier permeability. Mol Cell Biochem. 2015; 412(1-2):73-9. PMC: 4718828. DOI: 10.1007/s11010-015-2609-6. View

5.
Waly M, Al-Attabi Z, Guizani N . Low Nourishment of Vitamin C Induces Glutathione Depletion and Oxidative Stress in Healthy Young Adults. Prev Nutr Food Sci. 2015; 20(3):198-203. PMC: 4596346. DOI: 10.3746/pnf.2015.20.3.198. View