Effect of Laser Pulse Shaping on Photoacoustic Dosimetry in Retinal Models

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2020 Dec 7

PMID 33282510

Authors

Robert B Brown

Suzie Dufour

Pascal Deladurantaye

Nolwenn Le Bouch

Pascal Gallant

Sebastien Methot

Patrick J Rochette

Ozzy Mermut

Affiliations

Soon will be listed here.

Abstract

Photoacoustic sensing can be a powerful technique to obtain real-time feedback of laser energy dose in treatments of biological tissue. However, when laser therapy uses pulses with microsecond duration, they are not optimal for photoacoustic pressure wave generation. This study examines a programmable fiber laser technique using pulse modulation in order to optimize the photoacoustic feedback signal to noise ratio (SNR) in a context where longer laser pulses are employed, such as in selective retinal therapy. We have demonstrated with a homogeneous tissue phantom that this method can yield a greater than seven-fold improvement in SNR over non-modulated square pulses of the same duration and pulse energy. This technique was further investigated for assessment of treatment outcomes in leporine retinal explants by photoacoustic mapping around the cavitation-induced frequency band.

References

Lavinsky D, Wang J, Huie P, Dalal R, Lee S, Lee D . Nondamaging Retinal Laser Therapy: Rationale and Applications to the Macula. Invest Ophthalmol Vis Sci. 2016; 57(6):2488-500. PMC: 5995023. DOI: 10.1167/iovs.15-18981. View

Brinkmann R, Roider J, Birngruber R . Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results. Bull Soc Belge Ophtalmol. 2007; (302):51-69. View

Fan Q, Hu W, Ohta A . Efficient single-cell poration by microsecond laser pulses. Lab Chip. 2014; 15(2):581-8. PMC: 4304703. DOI: 10.1039/c4lc00943f. View

Bliedtner K, Seifert E, Brinkmann R . Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty. Transl Vis Sci Technol. 2019; 8(6):24. PMC: 6890396. DOI: 10.1167/tvst.8.6.24. View

Allen T, Beard P . Pulsed near-infrared laser diode excitation system for biomedical photoacoustic imaging. Opt Lett. 2006; 31(23):3462-4. DOI: 10.1364/ol.31.003462. View

Deladurantaye P, Methot S, Mermut O, Galarneau P, Rochette P . Potential of sub-microsecond laser pulse shaping for controlling microcavitation in selective retinal therapies. Biomed Opt Express. 2020; 11(1):109-132. PMC: 6968749. DOI: 10.1364/BOE.11.000109. View

Schuele G, Elsner H, Framme C, Roider J, Birngruber R, Brinkmann R . Optoacoustic real-time dosimetry for selective retina treatment. J Biomed Opt. 2006; 10(6):064022. DOI: 10.1117/1.2136327. View

Schuele G, Rumohr M, Huettmann G, Brinkmann R . RPE damage thresholds and mechanisms for laser exposure in the microsecond-to-millisecond time regimen. Invest Ophthalmol Vis Sci. 2005; 46(2):714-9. DOI: 10.1167/iovs.04-0136. View

Jacques S . Role of tissue optics and pulse duration on tissue effects during high-power laser irradiation. Appl Opt. 2010; 32(13):2447-54. DOI: 10.1364/AO.32.002447. View

10.

Petrova E, Ermilov S, Su R, Nadvoretskiy V, Conjusteau A, Oraevsky A . Using optoacoustic imaging for measuring the temperature dependence of Grüneisen parameter in optically absorbing solutions. Opt Express. 2013; 21(21):25077-90. PMC: 3867102. DOI: 10.1364/OE.21.025077. View

11.

Zemp R, Song L, Bitton R, Shung K, Wang L . Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer. Opt Express. 2008; 16(11):7915-28. PMC: 2717902. DOI: 10.1364/oe.16.007915. View

12.

Yao D, Zhang C, Maslov K, Wang L . Photoacoustic measurement of the Grüneisen parameter of tissue. J Biomed Opt. 2014; 19(1):17007. PMC: 3904038. DOI: 10.1117/1.JBO.19.1.017007. View

13.

Yucel Y, Cardinell K, Khattak S, Zhou X, Lapinski M, Cheng F . Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles. Invest Ophthalmol Vis Sci. 2018; 59(7):2699-2707. DOI: 10.1167/iovs.17-22850. View

14.

Lee H, Alt C, Pitsillides C, Lin C . Optical detection of intracellular cavitation during selective laser targeting of the retinal pigment epithelium: dependence of cell death mechanism on pulse duration. J Biomed Opt. 2008; 12(6):064034. DOI: 10.1117/1.2804078. View

15.

Framme C, Schuele G, Roider J, Birngruber R, Brinkmann R . Influence of pulse duration and pulse number in selective RPE laser treatment. Lasers Surg Med. 2004; 34(3):206-15. DOI: 10.1002/lsm.20022. View

16.

Sheinfeld A, Bergman E, Gilead S, Eyal A . The use of pulse synthesis for optimization of photoacoustic measurements. Opt Express. 2009; 17(9):7328-38. DOI: 10.1364/oe.17.007328. View

17.

Rohde I, Masch J, Theisen-Kunde D, Marczynski-Buhlow M, Bombien Quaden R, Lutter G . Resection of calcified aortic heart leaflets in vitro by Q-switched 2 µm microsecond laser radiation. J Card Surg. 2014; 30(2):157-62. DOI: 10.1111/jocs.12481. View

18.

Gao F, Feng X, Zheng Y, Ohl C . Photoacoustic resonance spectroscopy for biological tissue characterization. J Biomed Opt. 2014; 19(6):067006. DOI: 10.1117/1.JBO.19.6.067006. View

19.

Lavinsky D, Sramek C, Wang J, Huie P, Dalal R, Mandel Y . Subvisible retinal laser therapy: titration algorithm and tissue response. Retina. 2013; 34(1):87-97. DOI: 10.1097/IAE.0b013e3182993edc. View

20.

Vogt W, Jia C, Wear K, Garra B, Pfefer T . Biologically relevant photoacoustic imaging phantoms with tunable optical and acoustic properties. J Biomed Opt. 2016; 21(10):101405. PMC: 4756225. DOI: 10.1117/1.JBO.21.10.101405. View