Cell Adhesion Molecules and Protein Synthesis Regulation in Neurons

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2020 Dec 7

PMID 33281551

Citations 17

Authors

Irina Kozlova

Saroj Sah

Ryan Keable

Iryna Leshchynska

Michael Janitz

Vladimir Sytnyk

Affiliations

Soon will be listed here.

Abstract

Cell adhesion molecules (CAMs) mediate interactions of neurons with the extracellular environment by forming adhesive bonds with CAMs on adjacent membranes or binding to proteins of the extracellular matrix. Binding of CAMs to their extracellular ligands results in the activation of intracellular signaling cascades, leading to changes in neuronal structure and the molecular composition and function of neuronal contacts. Ultimately, many of these changes depend on the synthesis of new proteins. In this review, we summarize the evidence showing that CAMs regulate protein synthesis by modulating the activity of transcription factors, gene expression, protein translation, and the structure and distribution of organelles involved in protein synthesis and transport.

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