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Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance

Overview
Journal J Infect Dis
Publisher Oxford University Press
Specialty Infectious Diseases
Date 2020 Dec 1
PMID 33257936
Citations 19
Authors
Carleen Klumpp-Thomas
Heather Kalish
Jennifer Hicks
Jennifer Mehalko
Matthew Drew
Matthew J Memoli
Matthew D Hall
Dominic Esposito
Kaitlyn Sadtler
Affiliations
Soon will be listed here.
Abstract

Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics.

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