Ferritin As a Key Risk Factor for Nonalcoholic Fatty Liver Disease in Children with Obesity

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2020 Nov 29

PMID 33249617

Citations 7

Authors

Junfeng Zhang

Jiajia Cao

Hui Xu

Guanping Dong

Ke Huang

Wei Wu

Jingjing Ye

Junfen Fu

Affiliations

Soon will be listed here.

Abstract

Background: The association between serum ferritin and nonalcoholic fatty liver disease (NAFLD) in children with obesity is not clear. This study was designed to investigate whether serum ferritin can be an independent predictor for NAFLD.

Methods: According to the hepatic ultrasound results, a total of 347 children with obesity were enrolled in this study. Among them, 95 patients with NAFLD and 95 without NAFLD were matched for gender, age, blood pressure and body mass index, the odds ratios (OR) and 95% confidence intervals (CI) for the association of ferritin and the risk of NAFLD were analyzed.

Results: After propensity score matching, ferritin values of the patients with NAFLD were significantly higher than those without NAFLD group. Alanine aminotransferase and ferritin were strongly associated with NAFLD in multivariate stepwise logistic regression analysis. The medium and high levels of ferritin increased risk of NAFLD, and the adjusted ORs were 3.298 (95% CI:1.326-8.204), 7.322 (95% CI:2.725-19.574) across the ferritin concentration tertiles after adjustment for confounders. Ferritin was shown to be the best predictor for NAFLD with sensitivity and specificity of 60.0% and 77.9%, respectively, area under the curve was 0.733.

Conclusion: The results show that serum ferritin can usefully be considered as a predictor of NAFLD in children with obesity.

Citing Articles

Associations of Ultrasound Findings with Serum Iron and Ferritin Levels in Children with Obesity.

Stepan M, Vintilescu S, Ionele C, Dumitra G, Podeanu M, Bigea C Life (Basel). 2024; 14(4).

PMID: 38672754 PMC: 11051232. DOI: 10.3390/life14040484.

Analysis of risk factors for non-alcoholic fatty liver disease in hospitalized children with obesity before the late puberty stage.

Zhou L, Zhang L, Zhang L, Yi W, Yu X, Mei H Front Endocrinol (Lausanne). 2023; 14:1224816.

PMID: 37720532 PMC: 10501779. DOI: 10.3389/fendo.2023.1224816.

Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in Obese Children.

Zhang J, Guan J, Tang X, Xu J Horm Metab Res. 2023; 55(4):251-255.

PMID: 36849108 PMC: 10076105. DOI: 10.1055/a-2043-1044.

Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents.

He X, Wang W, Zhu Z, Zang J, Liu T, Shi Y Int J Environ Res Public Health. 2022; 19(23).

PMID: 36498311 PMC: 9740190. DOI: 10.3390/ijerph192316235.

The association between non-alcoholic fatty liver disease and serum ferritin levels in American adults.

Yang N, Lu Y, Cao L, Lu M J Clin Lab Anal. 2022; 36(2):e24225.

PMID: 34997649 PMC: 8841169. DOI: 10.1002/jcla.24225.

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