Myopericytoma Arising from Myopericytosis-a Hitherto Unrecognized Entity Within the Lung

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2020 Nov 27

PMID 33244708

Authors

Ulrike Gruber-Moesenbacher

Alicia Morresi-Hauff

Katja Behr

Helmut Popper

Affiliations

Soon will be listed here.

Abstract

Two cases of myopericytosis combined with pericytoma originating within the lung are reported. These are rare pulmonary tumors. The differential diagnosis for hemangiopericytoma and pericytic tumors with glomus elements is discussed. Both myopericytic lesions mimic other lesions, which are more commonly seen in the lung. Based on the expression of vascular growth factor receptors 2 and 3, an antiangiogenic therapy was suggested for the patient with the myopericytoma. A treatment with an angiogenesis inhibitor resulted in a regression of the tumor, but not the precursor lesion. Probably a more specific therapy using tyrosine kinase inhibitors for VEGFR2/3 might better control these myopericytic proliferations.

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