Cathepsin K Expression in Clear Cell "sugar" Tumor (PEComa) of the Lung

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2018 Mar 9

PMID 29516164

Citations 6

Authors

Anna Calio

Maria Cecilia Mengoli

Alberto Cavazza

Giulio Rossi

Claudio Ghimenton

Matteo Brunelli

Maurizio Pea

Marco Chilosi

Lisa Marcolini

Guido Martignoni

Affiliations

Soon will be listed here.

Abstract

Clear cell "sugar" tumor is a rare benign neoplasm arising in the lung, considered as a part of the PEComa family. As PEComas of other sites, this tumor expresses melanocytic markers such as HMB45 and Melan-A. Despite cathepsin K, MITF and CD68 staining are known to be positive in a large number of PEComas and TFE3 rearrangement has been reported in a subset of PEComas, no data is available regarding the expression of these markers and the occurrence of TFE3 and TFEB rearrangement in clear cell "sugar" tumor of the lung. We have investigated the immunolabeling of cathepsin K, MITF, and CD68 in five cases of clear cell "sugar" tumor. Moreover, we have also sought the presence of TFE3 and TFEB rearrangement by fluorescence in situ hybridization (FISH) assay. In all tumors, strong immunoreactivity of cathepsin K and CD68 (PG-M1 and KP1 clone) was demonstrated, whereas none of them labeled for MITF staining and showed TFE3 or TFEB rearrangement. These findings widen the immunohistochemical profile of clear cell "sugar" tumor providing useful new markers for challenging cases. The expression of lysosomal markers, such as cathepsin K and CD68, strengthens the hypothesis that this tumor is part of the PEComa family.

Citing Articles

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