Bioinformatics Analysis of Long Non-coding RNAs Involved in Nerve Regeneration Following Sciatic Nerve Injury

Overview

Journal Mol Pain

Date 2020 Nov 26

PMID 33241745

Citations 5

Authors

Yuanyuan Jia

Ming Zhang

Pei Li

Wenbo Tang

Yao Liu

Yiwen Hu

Qingjun Cui

Ming Liu

Jingjing Jiang

Affiliations

Soon will be listed here.

Abstract

Little is known about the role of epigenetic modification in axon regeneration following peripheral nerve injury. The purpose of the present study was to investigate the role of long non-coding RNAs (lncRNAs) in the regulation of axon regeneration. We used bioinformatics to perform microarray analysis and screened total 476 lncRNAs and 129 microRNAs (miRNAs) of differentially expressed genes after sciatic nerve injury in mice. lncRNA-GM4208 and lncRNA-GM30085 were examined, and the changes in lncRNA expression in the L4-L6 dorsal root ganglia (DRG) following sciatic nerve crush injury were analyzed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The expression of lncRNAs in the DRG changed, indicating that they might be related to nerve regeneration in the DRG following peripheral nerve injury.

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