Epigenome-wide Association Scan Identifies Methylation Sites Associated with HIV Infection

Overview

Journal Epigenomics

Specialty Genetics

Date 2020 Nov 24

PMID 33232214

Citations 6

Authors

Chang Shu

Andrew E Jaffe

Sarven Sabunciyan

Hongkai Ji

Jacquie Astemborski

Jing Sun

Kelly M Bakulski

Shruti H Mehta

Gregory D Kirk

Brion S Maher

Affiliations

Soon will be listed here.

Abstract

To investigate the role of epigenetics in HIV pathophysiology We conducted an epigenome-wide association scan on HIV infection status among people who inject drugs in the AIDS Linked to the IntraVenous Experience study with primary (n = 397) and validation samples (n = 390). DNA methylation from blood was measured by the Illumina EPIC BeadChip. We controlled for cell type heterogeneity by HIV status. HIV infection status was associated (p < 10) with DNA methylation at 49 CpG sites. Sites were enriched in response to virus, interferon signaling pathway, etc. Among these sites, discovery and validation t-statistics were highly correlated (r = 0.96). In a cohort of people who inject drugs, HIV status was associated with differential DNA methylation at biologically meaningful sites.

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