Ultradian Rhythms in Heart Rate Variability and Distal Body Temperature Anticipate Onset Of the Luteinizing Hormone Surge

Overview

Journal Sci Rep

Specialty Science

Date 2020 Nov 24

PMID 33230235

Citations 23

Authors

Azure D Grant

Mark Newman

Lance J Kriegsfeld

Affiliations

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Abstract

The menstrual cycle is characterized by predictable patterns of physiological change across timescales. Although patterns of reproductive hormones across the menstrual cycle, particularly ultradian rhythms, are well described, monitoring these measures repeatedly to predict the preovulatory luteinizing hormone (LH) surge is not practical. In the present study, we explored whether non-invasive measures coupled to the reproductive system: high frequency distal body temperature (DBT), sleeping heart rate (HR), sleeping heart rate variability (HRV), and sleep timing, could be used to anticipate the preovulatory LH surge in women. To test this possibility, we used signal processing to examine these measures in 45 premenopausal and 10 perimenopausal cycles alongside dates of supra-surge threshold LH and menstruation. Additionally, urinary estradiol and progesterone metabolites were measured daily surrounding the LH surge in 20 cycles. Wavelet analysis revealed a consistent pattern of DBT and HRV ultradian rhythm (2-5 h) power that uniquely enabled anticipation of the LH surge at least 2 days prior to its onset in 100% of individuals. Together, the present findings reveal fluctuations in distal body temperature and heart rate variability that consistently anticipate the LH surge, suggesting that automated ultradian rhythm monitoring may provide a novel and convenient method for non-invasive fertility assessment.

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References

HENANE R, Buguet A, Roussel B, Bittel J . Variations in evaporation and body temperatures during sleep in man. J Appl Physiol Respir Environ Exerc Physiol. 1977; 42(1):50-5. DOI: 10.1152/jappl.1977.42.1.50. View

Coyne M, Kesick C, Doherty T, Kolka M, Stephenson L . Circadian rhythm changes in core temperature over the menstrual cycle: method for noninvasive monitoring. Am J Physiol Regul Integr Comp Physiol. 2000; 279(4):R1316-20. DOI: 10.1152/ajpregu.2000.279.4.R1316. View

Vayena E, Tasioulas J . Adapting standards: ethical oversight of participant-led health research. PLoS Med. 2013; 10(3):e1001402. PMC: 3595203. DOI: 10.1371/journal.pmed.1001402. View

Keulers M, Hamilton C, Franx A, Evers J, Bots R . The length of the fertile window is associated with the chance of spontaneously conceiving an ongoing pregnancy in subfertile couples. Hum Reprod. 2007; 22(6):1652-6. DOI: 10.1093/humrep/dem051. View

Lessey B, Young S . What exactly is endometrial receptivity?. Fertil Steril. 2019; 111(4):611-617. DOI: 10.1016/j.fertnstert.2019.02.009. View

Moenter S, Caraty A, Locatelli A, Karsch F . Pattern of gonadotropin-releasing hormone (GnRH) secretion leading up to ovulation in the ewe: existence of a preovulatory GnRH surge. Endocrinology. 1991; 129(3):1175-82. DOI: 10.1210/endo-129-3-1175. View

Veldhuis J, Christiansen E, Evans W, Kolp L, Rogol A, Johnson M . Physiological profiles of episodic progesterone release during the midluteal phase of the human menstrual cycle: analysis of circadian and ultradian rhythms, discrete pulse properties, and correlations with simultaneous luteinizing hormone release. J Clin Endocrinol Metab. 1988; 66(2):414-21. DOI: 10.1210/jcem-66-2-414. View

Zavala E, Wedgwood K, Voliotis M, Tabak J, Spiga F, Lightman S . Mathematical Modelling of Endocrine Systems. Trends Endocrinol Metab. 2019; 30(4):244-257. PMC: 6425086. DOI: 10.1016/j.tem.2019.01.008. View

Baker F, Driver H . Circadian rhythms, sleep, and the menstrual cycle. Sleep Med. 2007; 8(6):613-22. DOI: 10.1016/j.sleep.2006.09.011. View

10.

Jain A, Polotsky A, Rochester D, Berga S, Loucks T, Zeitlian G . Pulsatile luteinizing hormone amplitude and progesterone metabolite excretion are reduced in obese women. J Clin Endocrinol Metab. 2007; 92(7):2468-73. DOI: 10.1210/jc.2006-2274. View

11.

Morch L, Skovlund C, Hannaford P, Iversen L, Fielding S, Lidegaard O . Contemporary Hormonal Contraception and the Risk of Breast Cancer. N Engl J Med. 2017; 377(23):2228-2239. DOI: 10.1056/NEJMoa1700732. View

12.

Schmalenberger K, Eisenlohr-Moul T, Wurth L, Schneider E, Thayer J, Ditzen B . A Systematic Review and Meta-Analysis of Within-Person Changes in Cardiac Vagal Activity across the Menstrual Cycle: Implications for Female Health and Future Studies. J Clin Med. 2019; 8(11). PMC: 6912442. DOI: 10.3390/jcm8111946. View

13.

Smarr B, Grant A, Zucker I, Prendergast B, Kriegsfeld L . Sex differences in variability across timescales in BALB/c mice. Biol Sex Differ. 2017; 8:7. PMC: 5301430. DOI: 10.1186/s13293-016-0125-3. View

14.

Yildirir A, Aybar F, Kabakci G, Yarali H, Oto A . Heart rate variability in young women with polycystic ovary syndrome. Ann Noninvasive Electrocardiol. 2006; 11(4):306-12. PMC: 6932634. DOI: 10.1111/j.1542-474X.2006.00122.x. View

15.

Bashan A, Bartsch R, Kantelhardt J, Havlin S, Ivanov P . Network physiology reveals relations between network topology and physiological function. Nat Commun. 2012; 3:702. PMC: 3518900. DOI: 10.1038/ncomms1705. View

16.

Williams H, Dacks P, Rance N . An improved method for recording tail skin temperature in the rat reveals changes during the estrous cycle and effects of ovarian steroids. Endocrinology. 2010; 151(11):5389-94. PMC: 2954718. DOI: 10.1210/en.2010-0630. View

17.

Genazzani A, Petraglia F, Volpogni C, DAmbrogio G, Facchinetti F, Genazzani A . FSH secretory pattern and degree of concordance with LH in amenorrheic, fertile, and postmenopausal women. Am J Physiol. 1993; 264(5 Pt 1):E776-81. DOI: 10.1152/ajpendo.1993.264.5.E776. View

18.

Skovlund C, Morch L, Kessing L, Lange T, Lidegaard O . Association of Hormonal Contraception With Suicide Attempts and Suicides. Am J Psychiatry. 2017; 175(4):336-342. DOI: 10.1176/appi.ajp.2017.17060616. View

19.

Polan M, Totora M, Caldwell B, DeCherney A, Haseltine F, Kase N . Abnormal ovarian cycles as diagnosed by ultrasound and serum estradiol levels. Fertil Steril. 1982; 37(3):342-7. DOI: 10.1016/s0015-0282(16)46093-0. View

20.

Epstein D, Lee N, Kang J, Agapie E, Schroeder J, Pina L . Examining Menstrual Tracking to Inform the Design of Personal Informatics Tools. Proc SIGCHI Conf Hum Factor Comput Syst. 2017; 2017:6876-6888. PMC: 5432133. DOI: 10.1145/3025453.3025635. View